CoVIC ID Antibody information Antibody features Affinity, KD (M) - Duke Pseudovirus neutralization (PNV-Luciferase; ng/mL) Pseudovirus neutralization - Beta (PNV-Luciferase; ng/mL) Pseudovirus neutralization - Delta (PNV-Luciferase; ng/mL) Authentic virus neutralization (Auth-luciferase ng/mL) - UNC Authentic virus neutralization (Auth-mNeonGreen ng/mL) - UTMB In vivo protection survival (%) Fc Activity - Ragon Complex formation inhibition (%) Antibody dependent enhancement UTMB - ADMP sequence / structural features Nexelis - PK UTMB - ADNKA Pseudovirus neutralization (PNV-GFP; % infected cells) Epitope Community (Full-length) Details
Unblinded ID Organization Isotype Epitope Community (RBD) D614 D614G RBD NTD B.1.351 Omicron IC50- Pseudovirus neutralization (ng/mL) IC80- Pseudovirus neutralization (ng/mL) IC90- Pseudovirus neutralization (ng/mL) IC50- Pseudovirus neutralization, Beta (ng/mL) IC80- Pseudovirus neutralization, Beta (ng/mL) IC90- Pseudovirus neutralization, Beta(ng/mL) IC50- Pseudovirus neutralization, Delta (ng/mL) IC80- Pseudovirus neutralization, Delta (ng/mL) IC90- Pseudovirus neutralization, Delta (ng/mL) IC50 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC80 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC90 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC50 (B.1.351)- Authentic virus neutralization, UNC (ng/mL) IC80 (B.1.351)- Authentic virus neutralization, UNC (ng/mL) IC50- UTMB - Authentic virus neutralization, UTMB (ng/mL) IC80- UTMB - Authentic virus neutralization, UTMB (ng/mL) IC90- UTMB - Authentic virus neutralization, UTMB (ng/mL) K18 mice hamsters ADCP mADCP ADNP mADNP ADCD (MFI C3) ADNKA % CD107a+ ADNKA % MIP-1b+ FcgR2aR (MFI) FcgR3aV (MFI) FcgR2b (MFI) FcgR3b (MFI) FcRn (MFI) mFcR2 (MFI) mFcR3 (MFI) mFcR4 (MFI) Spike: ACE2 Score (for level of ADE at 10 ug/mL) IC50- Antibody dependent enhancement IC80- Antibody dependent enhancement IC90- Antibody dependent enhancement Fold increase over virus control Escape Structure GMC for Pre-Spike IgG GMC for RBD IgG % CD107a+ Fold-change CD107a+ % IFNg+ Fold-change CD107a+ % TNFa+ Fold-change TNFa+ PNV-G (%infected; 250 ng/ml) PNV-G BETA (% infected; 250 ng/ml) PNV-L DELTA (IC50 ng/ml) PNV-G DELTA (%infected; 250 ng/ml) PNV-G BA.1 (%infected; 250 ng/ml) PNV-G BA.1.1 (%infected; 250 ng/ml) PNV-G BA.2 (%infected; 250 ng/ml) Community
CC12.3 None 5035 16232 54.642857142857146 1.4
Untreated Infected Control None None
Mock Infected Control None None
mAb-251 None 0.0
CR3022 None moderate weak weak moderate weak strong strong 5.99 6.11 4.78 5.73 3.94 5.12 5.3 6.16 nt nt nt nt nt nt nt D
KZ52 None weak moderate weak strong weak weak weak 4.06 3.84 4.38 3.7 3.78 3.59 4.4 4.29
negative plasma None weak moderate weak weak strong weak weak 4.01 3.79 4.33 3.7 3.76 3.58 4.33 4.2
CC12.14 None 1299 4989 2.1
1 IgG1 1 1.63e-09 1.75e-10 1.46e-06 4.19e-08 1830.0 6370.0 14100.0 2430.0 2510.0 2530.0 202.0 >25000 >25000 245 662 1.24e+03 1.65e+03 1.95e+03 weak moderate weak strong moderate weak moderate 6.09 6.05 5.48 4.83 3.5 3.93 4.87 5.66 69.6 1.2 20.50 0.90 1.32 1.02 0.05 0.06 54 100 202 14 91 100 100
2 IgG1 2b 1.24e-10 5.16e-11 1.23e-07 1.33e-11 1470.0 4010.0 7910.0 20.6 89.3 209.0 >25000 >25000 >25000 19 60 3.03e+02 4.69e+02 6.05e+02 10.0 strong strong strong strong moderate moderate moderate 6.34 6.28 6.01 6.42 5.65 5.96 5.89 6.63 100.0 2.0 Y489H 0.5mg/kg: 2065.60|1.5mg/kg: 7474.30 30.10 1.31 1.20 0.92 0.73 0.85 4 2 25000 92 94 100 93 H2
3 IgG1 2c 1.47e-09 8.3e-10 8.93e-07 2320.0 8360.0 16000.0 705.0 2850.0 4420.0 >25000 >25000 >25000 846 2766 3.20e+03 6.50e+03 9.84e+03 0.0 weak weak weak strong weak moderate moderate 5.87 5.99 5.0 4.39 3.63 3.94 4.68 5.03 90.3 1.12 1.5mg/kg: 1527.28 13.15 0.57 0.77 0.59 0.42 0.49 43 99 25000 13 95 100 84 H2
4 IgG1 2d 2.43e-10 8.05e-11 1.11e-07 1.84e-08 709.0 2480.0 5020.0 1530.0 1560.0 1570.0 759.0 5560.0 >25000 179 450 1.49e+03 2.73e+03 3.88e+03 moderate weak weak strong weak moderate weak 6.21 6.23 5.66 5.54 4.92 3.95 4.76 5.47 100.0 1.07 27.90 1.22 1.17 0.90 0.52 0.60 56 100 759 49 88 95 96 H2
5 IgG1 2c 1.08e-09 8.64e-10 3.98e-07 853.0 2600.0 5260.0 29.8 186.0 406.0 158.0 415.0 679.0 433 754 1.57e+04 1.84e+04 2.02e+04 0.0 weak weak weak moderate weak moderate moderate 6.05 6.08 5.36 5.14 4.56 3.94 4.77 5.14 98.2 1.23 1.5mg/kg: 1243.76 15.65 0.68 1.36 1.05 0.04 0.05 19 100 158 5 78 91 100 H2
6 IgG1 2a 5.53e-10 3.53e-10 8.71e-08 5.98e-10 >25000 >25000 >25000 >25000 >25000 >25000 21.4 102.0 249.0 11861 22679 2.52e+02 4.86e+02 7.14e+02 moderate moderate weak weak moderate moderate weak 6.05 5.94 5.65 5.87 4.09 4.59 5.11 5.91 99.0 1.28 22.65 0.99 1.34 1.03 0.89 1.03 91 100 21.4 59 81 96 98 A
7 IgG1 6b 1.21e-10 3.66e-11 1.72e-08 4.5e-06 4.92e-09 53.8 146.0 261.0 >25000 >25000 >25000 >25000 >25000 >25000 18 33 2.50e+04 2.50e+04 2.50e+04 10.0 moderate moderate moderate moderate weak moderate weak 6.09 6.0 5.71 5.98 4.58 4.57 4.92 6.15 100.0 2.51 0.5mg/kg: 1789.63|1.5mg/kg: 7481.71 21.40 0.93 1.57 1.21 0.07 0.08 3 100 25000 0 90 95 91 H1
8 IgG1 6b 6.75e-10 4.51e-10 2.36e-08 1.34e-10 12800.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2191 6355 1.02e+04 1.13e+04 1.21e+04 moderate weak moderate weak weak moderate weak 6.34 6.28 6.01 6.38 5.35 5.49 5.22 6.41 98.0 2.85 22.90 1.00 1.62 1.25 0.03 0.03 91 98 25000 56 86 96 83 A
9 IgG1 2c 1.65e-11 7.06e-12 2.33e-10 9.29e-08 3.63e-11 2.13e-08 12.6 24.0 34.1 >25000 >25000 >25000 1140.0 1170.0 1170.0 <0.32 0.54 3035 4766 4.83e+00 8.61e+00 1.21e+01 None weak weak weak moderate weak moderate weak 3.75 3.75 3.67 3.72 3.45 3.87 4.18 4.64 100.0 1.96 0.5mg/kg: 2099.34 23.45 1.02 1.18 0.90 0.14 0.17 0 93 1140 5 88 97 88 H3
10 IgG1 2c 1.84e-11 8.3e-12 2.04e-10 8.55e-08 3.92e-11 3.14e-08 10.1 21.2 32.7 464.0 2300.0 7470.0 51.2 325.0 907.0 <0.32 1 5862 15389 1.18e+01 2.19e+01 3.15e+01 None weak weak weak weak weak weak weak 3.78 3.74 3.7 3.71 3.46 3.86 4.26 4.24 100.0 1.29 0.5mg/kg: 3133.56 21.10 0.92 1.36 1.05 0.12 0.13 0 100 51.2 6 100 94 85 H3
11 IgG1 2c 2.35e-11 9.87e-12 2.11e-10 4.67e-08 2.81e-11 4.85e-09 6.09 16.2 28.0 >25000 >25000 >25000 159.0 656.0 1520.0 <0.32 0.93 137 196 1.78e+01 2.62e+01 3.28e+01 90.0 weak moderate weak moderate weak moderate weak 3.86 3.77 3.74 3.69 3.45 3.89 4.09 4.16 99.4 0.893 0.5mg/kg: 2060.71|1.5mg/kg: 8050.89 34.05 1.49 1.30 1.00 1.01 1.18 1 6 159 1 97 100 100 H3
12 IgG1 2c 1.11e-11 5.07e-12 1.64e-10 7.55e-08 4.24e-11 3.66e-08 7.48 18.6 30.6 990.0 1190.0 1250.0 352.0 1050.0 1450.0 <0.32 <0.32 2526 4536 8.62e+00 1.43e+01 1.93e+01 None weak strong weak strong weak moderate weak 3.67 3.75 3.62 3.71 3.45 3.88 4.14 4.2 100.0 2.42 0.5mg/kg: 2732.99 21.50 0.94 1.41 1.08 0.05 0.06 1 70 352 10 100 100 90 H3
13 IgG1 2c 8.95e-12 4.71e-12 1.16e-10 5.11e-08 2.42e-11 6.07 15.4 25.3 71.7 235.0 459.0 19.4 54.8 97.5 <0.32 0.85 159 627 4.75e+00 7.05e+00 8.88e+00 70.0 weak weak weak strong weak moderate moderate 4.04 4.43 3.8 3.72 3.48 3.91 4.82 4.76 100.0 3.3 0.5mg/kg: 4115.36|1.5mg/kg: 10520.90 9.65 0.42 2.07 1.59 0.47 0.55 1 41 19.4 1 98 90 92 H3
14 IgG1 2d 4.43e-11 1.1e-11 1.94e-09 1.14e-06 5.3e-11 5.45e-08 9.75 24.7 42.9 >25000 >25000 >25000 373.0 1490.0 7440.0 <0.32 <0.32 >12500 >12500 6.70e-01 1.42e+00 2.21e+00 strong strong strong strong moderate moderate strong 6.37 6.32 6.02 6.46 5.71 5.99 5.74 6.6 100.0 3.49 30.05 1.31 0.97 0.75 0.76 0.88 84 100 373 94 95 83 72 H3
15 IgG1 2d 9.47e-11 4.56e-11 1.19e-08 1.19e-07 1.22e-09 2.88e-09 32.0 107.0 223.0 >25000 >25000 >25000 1610.0 3140.0 3780.0 1 10 >12500 >12500 3.12e+01 4.93e+01 6.44e+01 strong strong strong strong strong moderate moderate 6.38 6.33 6.04 6.45 5.74 6.08 5.86 6.63 100.0 3.63 22.45 0.98 1.43 1.10 0.07 0.09 1 100 1610 28 80 85 79 H2
16 IgG1 2a 1.57e-10 5.04e-11 5.31e-09 1.03e-06 7.34e-10 9.66e-09 44.5 180.0 388.0 995.0 >25000 >25000 215.0 888.0 1380.0 10518 >25000 1.61e+04 8.58e+04 2.28e+05 moderate weak weak strong weak moderate moderate 6.15 6.15 5.36 3.9 5.09 3.94 4.91 5.04 100.0 1.54 83 100 215 56 89 84 78 H2
17 IgG1 4b 5.04e-10 4.01e-10 3.46e-08 1.81e-10 2.82e-09 1030.0 3020.0 5630.0 >25000 >25000 >25000 >25000 >25000 >25000 8726 24853 2.50e+04 2.50e+04 2.50e+04 strong moderate moderate moderate moderate moderate moderate 6.33 6.28 5.99 6.4 5.49 5.67 5.66 6.51 67.0 5.79 20.55 0.90 1.44 1.10 0.09 0.10 74 98 25000 83 79 74 74 G
18 IgG
19 IgG 1.08e-09 1.18e-09 2.64e-08 39.7 140.0 262.0 664.0 >25000 >25000 >25000 >25000 >25000 433 1516 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak moderate weak 4.07 3.8 3.83 3.73 3.45 3.93 4.75 4.54 23.7 1.42
20 IgG1 7.59e-10 8.13e-10 8.15e-08 1.36e-09 2.32e-09 72.3 587.0 >25000 639.0 1160.0 1350.0 >25000 >25000 >25000 236 4924 2.59e+03 9.47e+03 2.02e+04 10.0 strong moderate moderate strong strong moderate strong 6.09 6.0 5.77 6.02 4.23 4.57 5.23 6.07 9.0 3.64 0.5mg/kg: 50.30|1.5mg/kg: 58.71 24.15 1.05 1.61 1.24 0.14 0.16 12 100 25000 84 90 83 79
21 IgG1 7c 5.02e-10 1.4e-09 2.08e-10 5.25e-10 9.26e-09 12500.0 >25000 >25000 162.0 >25000 >25000 >25000 >25000 >25000 8582 20807 1.99e+04 3.48e+04 4.82e+04 0.0 strong moderate moderate moderate moderate moderate weak 6.29 6.22 5.95 6.3 5.2 5.14 5.34 6.28 11.6 2.69 0.5mg/kg: 134.98|1.5mg/kg: 643.01 40.20 1.76 2.06 1.58 0.51 0.59 99 100 25000 81 91 96 77
22 IgG1 6a 1.08e-09 3e-09 1.04e-07 3.68e-10 1.84e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak moderate weak weak moderate weak 6.24 6.2 5.89 6.22 5.0 4.63 5.2 6.11 51.1 2.95 1.5mg/kg: 1601.37 12.20 0.53 6.80 5.23 0.73 0.85 90 100 25000 71 97 100 79
23 IgG1 5b 3.72e-10 5.86e-10 7.13e-08 2e-10 4.25e-09 14200.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong moderate moderate weak moderate moderate weak 6.27 6.22 5.93 6.27 4.82 5.04 5.09 6.27 36.3 5.49 1.5mg/kg: 158.53 18.15 0.79 1.63 1.25 0.12 0.13 87 100 25000 87 90 90 82 E4
24 IgG1 7b 1.21e-09 2.3e-09 1.46e-08 7.49e-10 2.55e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 14175 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 moderate strong weak weak weak strong moderate 6.22 6.18 5.86 6.23 5.08 4.78 5.17 6.21 48.7 3.48 1.5mg/kg: 3119.58 33.00 1.44 0.84 0.65 1.14 1.33 100 100 25000 86 98 100 91
25 IgG1 7b 1.07e-09 1.9e-09 8.49e-08 6.96e-09 8.2e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate strong moderate weak moderate moderate 5.77 5.93 5.07 5.59 3.78 4.02 4.91 5.71 31.2 2.47 21.40 1.15 1.68 5.00 0.63 1.05 89 100 25000 98 100 95 95
26 IgG1 7b 6.57e-10 1.18e-09 3.88e-08 5.36e-09 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak moderate strong weak moderate moderate 6.22 6.14 5.81 6.16 4.75 4.54 5.25 6.14 31.8 5.8 1.5mg/kg: 630.67 19.20 1.04 0.84 2.52 0.46 0.76 82 99 25000 85 89 95 100
27 IgG1 3a 3.59e-09 1.42e-09 1.48e-07 2.62e-10 8.91e-08 8250.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 260 2457 1173 4632 2.07e+04 3.24e+04 4.22e+04 strong moderate moderate strong weak moderate moderate 6.19 6.13 5.87 6.24 5.23 5.04 5.3 6.34 88.6 6.13 24.55 1.32 1.69 5.04 0.61 1.02 72 92 25000 68 80 90 89 A
28 IgG1 6b 3.3e-10 5.22e-10 1.23e-08 1.26e-10 2.32e-08 512.0 1960.0 3960.0 755.0 1400.0 1760.0 308.0 >25000 >25000 190 815 398 897 3.19e+03 4.68e+03 5.85e+03 0.0 strong moderate moderate strong weak moderate moderate 6.36 6.3 6.02 6.42 5.63 5.9 5.61 6.55 100.0 6.13 0.5mg/kg: 1908.96|1.5mg/kg: 3954.73 27.10 1.46 1.84 5.49 0.67 1.12 57 65 308 37 75 86 84 A
29 IgG1 4.33e-10 3.5e-10 3.99e-07 1020.0 1520.0 1750.0 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate weak weak strong weak moderate weak 6.24 6.18 5.89 6.2 4.64 4.74 5.15 6.16 5.0 19.25 1.04 0.77 2.28 0.68 1.13 84 100 25000 77 81 84 77 E2
30 IgG1 2d 3.21e-11 5.94e-12 4.1e-09 2.73e-06 8.87 26.8 50.7 518.0 1650.0 >25000 47.1 113.0 200.0 2 6 >25000 >25000 2.75e+01 5.23e+01 7.61e+01 100.0 strong strong strong moderate moderate moderate moderate 6.36 6.3 6.02 6.45 5.72 6.06 5.53 6.59 100.0 7.37 E484A 0.5mg/kg: 2456.41|1.5mg/kg: 8195.59 25.45 1.37 1.31 3.91 0.59 0.99 0 100 47.1 3 74 80 81 H3
31 IgG1 4b 1.42e-10 8.08e-11 7.02e-08 3.96e-10 11400.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 949 2233 1.21e+04 4.33e+04 9.12e+04 10.0 strong weak moderate moderate moderate moderate moderate 6.3 6.26 5.97 6.4 5.68 6.03 5.67 6.6 99.0 2.57 1.5mg/kg: 2850.55 24.85 1.34 0.96 2.87 0.80 1.33 74 100 25000 52 83 79 78 G
32 IgG1 2d 5.76e-11 1.85e-11 1.76e-09 1.96e-06 2.04e-10 8.66 32.3 66.4 >25000 >25000 >25000 1.08 1.06 1.06 2 8 735 2676 6.11e+01 1.44e+02 2.37e+02 60.0 strong strong strong moderate moderate moderate weak 6.39 6.32 6.05 6.46 5.72 6.08 5.68 6.61 100.0 2.65 G496V|S494L 0.5mg/kg: 3150.21|1.5mg/kg: 6774.03 26.20 1.41 0.74 2.22 0.78 1.29 0 89 1.08 73 83 80 72 H3
33 IgG1 3.32e-08 1.63e-08 4.8e-06 8.18e-08 >25000 >25000 >25000 >25000 >25000 >25000 5650.0 7400.0 7930.0 18 44 259 637 4.57e+03 6.06e+03 7.14e+03 10.0 strong weak weak weak weak moderate moderate 4.35 4.01 3.81 3.77 3.48 3.94 4.91 5.23 7.6 3.29 24.30 1.31 0.56 1.67 0.91 1.52 46 100 5650 81 86 81 70
34 IgG1 2.37e-09 1.74e-09 3.92e-09 5.29e-08 162.0 453.0 1050.0 1.13 1.12 1.12 >25000 >25000 >25000 201 19356 1.02e+04 2.14e+04 3.30e+04 0.0 moderate moderate weak weak weak moderate strong 6.0 5.97 5.52 5.7 4.31 4.12 5.01 5.71 6.4 2.3 1.5mg/kg: 50.30 19.80 1.07 0.84 2.51 0.94 1.57 14 99 25000 75 86 72 74
35 IgG1 7c 1.68e-09 1.05e-09 2.81e-09 4.34e-10 2.3e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong strong moderate weak weak moderate weak 6.21 6.2 5.9 6.25 5.33 5.21 5.31 6.22 7.1 3.24 1.5mg/kg: 1842.61 24.50 1.32 0.76 2.25 0.59 0.99 90 100 25000 80 94 82 74
36 IgG1 4.36e-09 4.96e-09 9.51e-07 86.2 6600.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 4 14 >25000 >25000 3.07e+01 1.18e+02 2.59e+02 60.0 moderate moderate weak weak weak moderate weak 6.18 6.11 5.87 6.18 5.04 5.07 5.06 6.21 3.1 del68-70 0.5mg/kg: 63.45 23.85 1.29 0.61 1.82 0.15 0.25 30 100 25000 85 100 84 87
37 IgG1 1.9e-08 3.96e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak weak weak moderate weak 5.19 5.28 4.44 4.15 3.53 3.92 4.86 5.2 3.9 0.459 22.15 1.19 0.64 1.91 1.16 1.93 87 100 25000 90 98 92 100
38 IgG 6b 1.09e-09 4.54e-10 7.05e-09 1.4e-10 297.0 1310.0 2900.0 863.0 2170.0 2740.0 376.0 1820.0 2920.0 16 78 41 123 3.45e+02 7.16e+02 1.10e+03 None moderate moderate moderate strong moderate moderate strong 6.35 6.3 6.01 6.42 5.52 5.76 5.48 6.45 99.3 1.05 0.5mg/kg: 176.64 21.40 1.15 0.59 1.76 0.54 0.90 31 24 376 7 92 90 87 A
39 IgG 2d 3.12e-11 1.06e-11 1.78e-09 1.66e-06 3.33e-08 4.13e-08 7.11 20.1 35.8 >25000 >25000 >25000 124.0 333.0 750.0 <0.32 <0.32 12500 12500 1.66e+01 2.68e+01 3.56e+01 None strong strong strong strong moderate moderate moderate 6.36 6.32 6.03 6.47 5.71 6.01 5.7 6.61 100.0 1.47 L452P 0.5mg/kg: 3296.86 24.60 1.33 0.98 2.94 0.86 1.43 0 100 124 6 82 91 82 H3
40 IgG 2d 7.15e-11 3.82e-11 1.68e-08 6.92e-09 4.03e-08 248.0 825.0 1590.0 >25000 >25000 >25000 289.0 1540.0 3400.0 76 216 >25000 >25000 4.76e+02 1.46e+03 2.80e+03 None strong moderate strong strong weak moderate moderate 6.37 6.31 6.03 6.45 5.71 6.06 5.82 6.63 100.0 0.868 F490C|F490L|F490V 0.5mg/kg: 1926.61 18.80 1.01 0.47 1.42 0.91 1.52 24 85 289 9 87 90 87 H3
41 IgG1 2.33e-10 2.49e-10 2.75e-08 1.06e-10 7.77e-10 6450.0 23200.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 5997 >25000 2.50e+04 2.50e+04 2.50e+04 100.0 strong weak moderate moderate weak moderate weak 6.3 6.25 5.95 6.35 5.51 5.6 4.6 6.36 1.02 1.5mg/kg: 15897.03 23.00 1.24 0.66 1.97 1.05 1.76 82 100 25000 70 89 82 88
42 IgG1 2a 4.84e-10 1.59e-10 1.1e-08 4.47e-10 57.6 185.0 348.0 1000.0 21700.0 >25000 13.8 53.8 124.0 14 44 2246 6637 7.81e+02 1.81e+03 2.95e+03 0.0 strong moderate strong moderate moderate moderate moderate 6.37 6.3 6.02 6.45 5.61 5.87 5.44 6.56 98.8 0.626 0.5mg/kg: 3894.89 21.45 1.16 0.41 1.22 0.40 0.67 6 74 13.8 1 83 95 81 H1
43 IgG4 2c 1.94e-10 9.59e-11 2.27e-08 1.48e-08 34.1 109.0 210.0 >25000 >25000 >25000 3.2 17.5 47.5 13 31 1672 3234 1.22e+03 2.06e+03 2.81e+03 10.0 strong weak moderate weak weak moderate moderate 6.38 6.11 6.01 3.8 5.72 4.02 4.25 4.98 100.0 0.718 0.5mg/kg: 206.34|1.5mg/kg: 778.93 22.20 1.20 0.82 2.46 0.83 1.39 0 100 3.2 1 90 85 75
44 IgG1 2c 1.42e-10 1.98e-10 4.74e-08 53.4 163.0 302.0 >25000 >25000 >25000 102.0 265.0 432.0 5 19 >25000 >25000 4.26e+02 1.01e+03 1.66e+03 30.0 strong moderate moderate moderate weak moderate weak 6.3 6.24 5.98 6.4 5.61 5.94 5.57 6.53 100.0 1.41 1.5mg/kg: 1312.88 24.15 1.30 0.78 2.31 0.80 1.33 2 100 102 1 77 88 65
45 IgG4 2c 1.7e-10 3.6e-11 3.67e-08 8.06 27.7 55.2 >25000 >25000 >25000 5.47 28.6 68.7 2 8 >25000 >25000 1.04e+02 1.56e+02 1.98e+02 30.0 moderate weak moderate weak weak moderate weak 6.37 6.2 6.02 3.82 5.69 4.03 4.29 5.44 100.0 1.85 0.5mg/kg: 372.94|1.5mg/kg: 1152.88 18.90 1.02 0.66 1.96 0.72 1.20 2 100 5.47 1 74 75 63
46 IgG1 2.98e-09 3.14e-08 >25000 >25000 >25000 2230.0 3430.0 3800.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.14 3.92 3.84 3.72 3.5 3.9 4.85 5.39 6.5 1.23 35.20 1.90 0.76 2.27 0.63 1.05 94 100 2230 74 88 82 70
47 IgG4 2.73e-09 3.18e-09 3.55e-08 4610.0 11000.0 18900.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.54 4.86 3.98 4.25 3.69 3.92 4.85 4.63 24.4 2.53 T588A 23.10 1.25 0.59 1.76 0.94 1.57 90 100 25000 77 91 74 81
48 IgG1 2a 4.28e-10 1.51e-10 1.22e-07 2.19e-08 1150.0 3620.0 13300.0 >25000 >25000 >25000 115.0 696.0 >25000 426 1028 2.82e+03 4.63e+03 6.18e+03 moderate moderate weak weak weak moderate weak 6.22 6.17 5.86 6.22 4.61 4.46 5.02 6.13 100.0 3.14 23.35 1.26 1.07 3.19 0.52 0.86 57 100 115 9 98 77 81
49 IgG4 2a 3.41e-10 1.36e-10 1.48e-07 1.39e-08 57.4 219.0 506.0 2540.0 3720.0 4100.0 35.7 133.0 259.0 110 256 2.24e+03 9.30e+03 2.14e+04 0.0 moderate moderate moderate weak weak weak weak 6.13 5.75 5.88 3.74 5.57 3.98 4.58 4.61 100.0 2.67 1.5mg/kg: 1233.73 23.80 1.28 0.92 2.75 0.58 0.97 26 100 35.7 2 99 91 91
50 IgG1 2a 4.68e-10 1.75e-10 7.87e-08 1.89e-08 869.0 3110.0 6470.0 >25000 >25000 >25000 116.0 398.0 1480.0 70 322 >25000 >25000 4.58e+03 1.11e+04 1.87e+04 strong weak moderate strong weak moderate moderate 6.23 6.19 5.86 6.21 4.63 4.58 5.14 6.12 100.0 1.27 K417E 25.95 1.40 0.92 2.73 0.67 1.11 28 100 116 3 79 93 90
51 IgG1 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak strong weak moderate strong 4.48 3.87 3.79 3.72 3.46 3.94 4.92 4.72 13.5 0.716 25.80 1.39 1.22 3.64 0.61 1.02 89 99 25000 54 82 79 74
52 IgG1 2a 2.47e-10 1.57e-10 1.71e-09 6.94e-09 221.0 606.0 1080.0 >25000 >25000 >25000 134.0 471.0 739.0 64 187 >25000 >25000 6.07e+02 1.49e+03 2.52e+03 0.0 strong moderate strong strong moderate moderate moderate 6.36 6.29 6.02 6.44 5.65 5.87 5.41 6.56 95.0 1.38 Y489H 1.5mg/kg: 4210.07 24.65 1.33 1.07 3.19 0.55 0.92 18 99 134 6 82 84 75 H2
53 IgG1 6e-10 2.37e-08 189.0 801.0 1730.0 34.7 185.0 524.0 86.5 559.0 1130.0 95 242 249 800 5.91e+03 9.09e+03 1.17e+04 0.0 moderate weak weak strong weak moderate moderate 5.45 5.44 4.8 4.96 3.5 3.92 4.86 5.19 70.0 1.04 1.5mg/kg: 50.30 22.45 1.21 1.10 3.28 0.68 1.13 100 100 86.5 59 54 55 56
54 7a 8.65e-10 2.44e-09 2.44e-07 8.76e-11 1.58e-08 37.0 87.4 139.0 26.4 68.2 111.0 12.9 37.8 64.4 6 22 2 6 2.44e+02 3.44e+02 4.21e+02 weak weak weak moderate weak moderate weak 4.19 3.75 3.86 3.74 3.47 3.9 4.94 4.6 99.5 0.864 S375F|S375F,D1118H 6.90 0.37 0.47 1.40 0.58 0.97 1 3 12.9 0 39 34 96 C2
55 IgG1 1.56e-10 5.8e-11 1.15e-07 3.12e-11 1.81e-08 13.1 38.3 70.7 5.98 23.0 48.2 5.47 17.0 30.6 13 27 60 125 2.49e+02 3.85e+02 4.97e+02 0.0 strong moderate moderate strong moderate moderate strong 6.37 6.28 6.01 6.42 5.59 5.74 5.53 6.45 100.0 1.12 1.5mg/kg: 142.39 24.20 1.30 0.94 2.79 1.04 1.73 0 0 5.47 0 2 2 77 C2
56 IgG1 1.13e-10 3.82e-11 9.42e-08 1.64e-05 3e-11 1.83e-08 6.36 24.3 51.7 1.52 6.68 16.5 1.74 5.53 10.5 2 7 6 20 1.02e+02 1.77e+02 2.44e+02 0.0 strong weak moderate strong weak moderate moderate 6.33 6.23 5.96 6.34 5.41 5.27 5.34 6.32 100.0 1.86 1.5mg/kg: 50.30 26.50 1.43 1.19 3.54 0.51 0.85 0 0 1.74 0 1 1 72 C2
57 1.36e-09 2.28e-09 2.04e-07 1.53e-10 4.16e-09 10.2 26.1 45.3 1.06 3.54 7.11 3.08 9.16 17.7 1 5 3 13 5.15e+01 1.21e+02 1.99e+02 92.7 0.66 19.60 1.06 1.23 3.66 0.60 1.00 0 0 3.08 0 3 1 71 C2
58 IgG1 7a 2.98e-09 9.59e-10 1.39e-07 5.68e-11 4.6 13.6 24.7 0.805 3.1 6.51 0.45 1.74 3.19 5 16 14 27 8.74e+01 1.11e+02 1.27e+02 strong moderate weak strong weak weak weak 5.29 5.52 3.75 3.65 4.13 4.15 5.41 5.29 100.0 2.12 20.80 1.12 0.85 2.54 0.90 1.49 0 1 0.45 0 3 2 69 C2
59 7a 4.76e-10 1.2e-09 2.01e-07 7.63e-11 1.16e-08 3.7 11.8 22.5 1.24 4.07 9.24 2.75 10.4 17.7 1 1 <0.32 4 8.90e+01 1.16e+02 1.35e+02 weak weak weak weak weak moderate weak 3.98 3.75 3.8 3.73 3.46 3.9 4.83 4.7 99.4 0.957 S371F 21.00 1.11 1.64 3.28 0.99 2.91 0 2 2.75 0 1 1 72 C2
60 0.45 2 0.37 2 1.34e+01 2.07e+01 2.66e+01 0.486 20.20 1.07 1.34 2.69 0.55 1.62 0 0 0 1 2 88
61 7a 6.2e-10 1.3e-09 1.95e-07 5.25e-11 2.04e-09 4.96 15.8 30.8 0.886 4.0 10.2 2.28 8.63 18.5 2 5 <0.32 3 9.05e+01 1.32e+02 1.65e+02 weak moderate weak weak weak moderate weak 4.04 3.78 3.78 3.7 3.46 3.91 4.9 4.86 99.5 0.996 D442A 19.50 1.03 1.29 2.59 1.77 5.21 1 0 2.28 0 2 1 96 C2
62 IgG1 7a 2.04e-10 4.77e-11 6.38e-08 1.61e-05 3.55e-11 1.47e-08 8.46 34.5 74.3 4.14 14.1 27.5 7.96 26.0 49.2 4 8 4 15 1.84e+02 3.76e+02 5.71e+02 0.0 moderate strong moderate strong weak moderate moderate 6.32 6.24 5.97 6.36 5.41 5.04 5.32 6.29 100.0 1.32 1.5mg/kg: 50.63 23.45 1.24 1.54 3.09 0.67 1.96 0 0 7.96 1 0 0 87 C2
63 7a 4.52e-10 1.07e-09 1.85e-07 6.04e-11 4.26e-09 2.75 10.8 23.4 >25000 >25000 >25000 4.05 11.0 19.1 <0.32 1 <0.32 0.48 1.64e+01 3.65e+01 5.84e+01 weak moderate weak weak weak moderate weak 4.36 3.83 3.78 3.73 3.47 3.93 4.93 4.43 99.8 1.35 Y508H 20.85 1.10 1.25 2.50 0.51 1.50 0 0 4.05 1 2 1 90 C2
64 7a 7.08e-10 1.3e-09 1.69e-07 1.34e-10 1.85e-08 11.6 24.6 39.2 25.5 68.3 93.9 2.53 10.3 20.1 3 13 <0.32 4 6.20e+01 8.84e+01 1.09e+02 weak moderate weak weak weak moderate weak 3.94 3.8 3.82 3.73 3.46 3.92 4.86 4.41 96.6 1.16 del374,Y508H|del374,D571G 22.40 1.18 1.49 2.98 0.62 1.84 0 0 2.53 1 9 6 95 C3
65 IgG1 7a 1.01e-10 4.01e-11 5.1e-08 2.84e-11 1.92e-08 10.8 29.2 51.1 1.01 5.96 11.1 3.02 10.4 21.1 16 26 18 36 2.50e+02 4.05e+02 5.37e+02 moderate weak moderate strong weak moderate moderate 6.32 6.27 5.97 6.42 5.65 5.77 5.61 6.48 100.0 1.72 K417E 21.40 1.13 1.45 2.90 0.68 1.99 0 0 3.02 0 6 6 96 C3
66 5.89e-10 1.14e-09 1.4e-07 1.29e-10 1.88e-08 4.17 11.0 19.5 4.47 15.2 31.9 8.61 26.7 49.6 1 3 <0.32 4 1.12e+02 3.10e+02 5.62e+02 weak weak weak strong weak moderate strong 4.28 4.07 3.88 3.85 3.47 3.9 4.94 4.75 100.0 1.18 21.75 1.15 1.65 3.30 0.71 2.10 0 0 8.61 0 4 8 73 C3
67 IgG1 2a 1.39e-09 6.13e-10 2.85e-07 1.81e-10 7.33e-08 17500.0 >25000 >25000 >25000 >25000 >25000 21.7 419.0 1160.0 3404 12080 1.99e+03 3.49e+03 4.85e+03 0.0 strong weak moderate strong weak moderate moderate 6.19 6.13 5.77 6.15 4.77 4.67 5.22 6.22 100.0 1.33 0.5mg/kg: 152.54|1.5mg/kg: 665.62 23.10 1.22 1.30 2.60 0.56 1.65 62 70 21.7 29 78 92 83
68 IgG1 2d 4.3e-11 3.61e-11 2.89e-09 2.82e-07 2.05e-09 2.36e-09 9.83 25.8 43.8 >25000 >25000 >25000 10.3 30.1 54.8 1 1 >25000 >25000 5.93e+01 8.74e+01 1.10e+02 None strong strong strong strong moderate moderate strong 6.39 6.33 6.03 6.46 5.73 6.14 5.91 6.59 100.0 1.47 0.5mg/kg: 736.35 40.55 2.14 2.33 4.65 1.39 4.07 0 98 10.3 0 88 90 91 H2
69 IgG1 1 1.36e-09 2.2e-10 2.67e-08 7.05e-11 8.92e-10 6840.0 20200.0 >25000 262.0 >25000 >25000 558.0 1730.0 2320.0 482 2470 2.50e+04 2.50e+04 2.50e+04 0.0 strong moderate moderate moderate weak moderate strong 6.32 6.26 5.99 6.41 5.61 5.88 5.28 6.56 74.1 2.52 1.5mg/kg: 501.00 33.90 1.79 1.05 2.11 1.07 3.16
70 2.62e-09 3.79e-09 1.3e-07 6.34e-09 606.0 3820.0 9900.0 >25000 >25000 >25000 >25000 >25000 >25000 4929 19977 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak weak weak 4.21 3.9 3.89 3.75 3.48 3.93 5.0 4.72 86.9 1.11 24.75 1.31 1.30 2.61 0.55 1.62
71 2.51e-09 1.27e-09 1.29e-07 5.91e-10 876.0 5810.0 18200.0 >25000 >25000 >25000 >25000 >25000 >25000 18221 >25000 >12500 >12500 2.50e+04 2.50e+04 2.50e+04 weak weak moderate moderate weak moderate moderate 4.2 3.87 3.85 5.34 3.47 3.92 5.02 4.72 90.1 1.26 23.55 1.24 1.45 2.90 0.66 1.94
72 2.8e-09 3.72e-09 3.14e-08 5.65e-09 137.0 536.0 1110.0 >25000 >25000 >25000 189.0 913.0 2190.0 362 898 >12500 >12500 5.20e+02 1.01e+03 1.48e+03 weak moderate moderate weak weak moderate moderate 4.16 3.81 3.82 3.72 3.48 3.91 4.81 4.43 98.8 0.639
73 2a 2.85e-09 4.54e-09 2.49e-08 6.99e-09 302.0 1460.0 3270.0 >25000 >25000 >25000 >25000 >25000 >25000 364 1119 >12500 >12500 3.13e+03 5.68e+03 8.04e+03 weak weak weak weak weak moderate moderate 4.21 4.07 3.87 3.72 3.47 3.95 4.95 4.63 100.0 1.45 37.85 2.00 2.06 4.11 1.43 4.21 66 100 25000 36 95 95 100
74 IgG1 3a 5.52e-10 2.73e-10 3.42e-08 1.44e-10 5.56e-08 78.2 2600.0 9560.0 >25000 >25000 >25000 >25000 >25000 >25000 78 543 44 220 1.55e+03 3.63e+03 5.96e+03 0.0 strong strong moderate weak weak moderate strong 6.22 6.18 5.9 6.27 5.25 4.99 5.28 6.37 96.2 1.7 0.5mg/kg: 511.23|1.5mg/kg: 1286.76 34.55 1.82 1.65 3.30 1.82 5.37 40 68 25000 24 96 98 89
75 IgG1 3a 2.49e-09 1.18e-09 1.27e-07 3.92e-10 8.85e-08 9650.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 379 3034 689 3668 2.50e+04 2.50e+04 2.50e+04 moderate strong moderate weak weak moderate moderate 6.13 6.1 5.8 6.2 5.09 4.88 5.15 6.25 91.3 1.68 35.65 1.88 2.00 4.00 1.45 4.25 63 93 25000 64 94 96 94
76 IgG1 3a 3.62e-09 1.46e-09 1.77e-07 9.63e-10 5.26e-08 17600.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 3548 11060 2214 10897 2.50e+04 2.50e+04 moderate moderate moderate weak weak moderate weak 5.99 6.03 5.71 6.08 4.5 4.42 5.13 6.11 92.6 2.7 20.25 1.07 1.70 3.40 0.81 2.40 67 91 25000 60 93 95 80
77 IgG1 3a 4.34e-09 1.79e-09 3.86e-07 1.07e-09 24600.0 >25000 >25000 >25000 >25000 >25000 833.0 1010.0 1070.0 2.50e+04 2.50e+04 2.50e+04 moderate weak moderate strong weak moderate moderate 5.83 5.82 5.25 5.54 3.5 3.94 4.89 5.53 78.3 1.31 21.05 1.11 2.21 4.42 0.87 2.56 81 100 833 79 91 93 90
78 IgG1 5a 7.18e-10 1.87e-10 3.93e-07 1.35e-10 74.2 224.0 663.0 44.9 164.0 519.0 >25000 >25000 >25000 12 44 10 33 4.61e+01 8.75e+02 4.90e+03 100.0 strong weak moderate strong weak moderate moderate 6.23 6.21 5.91 6.32 5.5 5.57 5.57 6.44 48.7 2.42 del68-69,V70I 0.5mg/kg: 285.14|1.5mg/kg: 1432.71 38.55 2.03 1.95 3.90 1.49 4.37 17 38 25000 18 89 96 88 F
79 IgG1 2a 8.78e-11 6.21e-11 7.45e-10 2.89e-07 3.51e-10 1.01e-08 53.7 140.0 235.0 315.0 >25000 >25000 39.1 80.6 129.0 0.38 3 379 747 2.38e+01 1.76e+02 5.68e+02 10.0 strong strong strong strong moderate moderate moderate 6.36 6.3 6.02 6.43 5.64 5.9 5.43 6.55 99.1 2.93 1.5mg/kg: 8009.08 31.95 1.69 1.73 3.45 2.31 6.78 1 34 39.1 1 32 38 37 H1
80 IgG1 3a 2.18e-09 1.21e-09 1.04e-07 5.09e-10 792.0 3340.0 7600.0 371.0 3670.0 >25000 232.0 1270.0 >25000 222 1595 978 3872 3.58e+03 8.52e+03 1.42e+04 0.0 strong moderate moderate strong weak moderate moderate 6.17 6.18 5.88 6.27 5.45 5.36 5.37 6.37 93.7 1.98 1.5mg/kg: 2316.58 31.85 1.68 1.46 2.91 1.27 3.75 52 64 232 27 81 81 76
81 IgG1 3a 1.47e-09 8.4e-10 9.88e-08 1.52e-10 7.16e-08 824.0 4140.0 9950.0 1390.0 >25000 >25000 227.0 >25000 >25000 100 627 268 736 4.31e+03 1.24e+04 2.30e+04 0.0 strong moderate moderate moderate weak moderate weak 6.19 6.13 5.85 6.24 5.28 5.16 5.26 6.3 86.8 3.09 0.5mg/kg: 397.89|1.5mg/kg: 1106.86 24.85 1.31 2.05 4.10 0.60 1.78 54 75 227 39 93 83 73 B
82 IgG1 7b 1.28e-09 1.9e-09 3.61e-08 1.02e-09 3.29e-08 >25000 >25000 >25000 >25000 >25000 >25000 1950.0 3020.0 3360.0 20205 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak weak weak weak moderate moderate 6.04 6.01 5.61 5.94 4.02 4.12 5.03 5.8 33.1 3.82 1.5mg/kg: 1030.22 27.35 1.44 1.12 2.24 1.23 3.60 87 100 1950 83 96 81 77
83 7a 3.73e-10 2.14e-10 8.94e-08 6.75e-11 4.35e-08 1030.0 3200.0 6030.0 335.0 1140.0 1700.0 380.0 >25000 >25000 99 396 172 503 2.50e+03 2.90e+03 3.16e+03 10.0 strong weak moderate moderate weak moderate moderate 6.3 6.22 5.94 6.28 5.04 5.1 5.29 6.26 98.0 3.84 0.5mg/kg: 1033.55|1.5mg/kg: 9035.08 43.85 2.31 1.82 3.65 1.62 4.76 44 36 380 8 100 90 77 B
84 7a 4.33e-10 2.78e-10 9.29e-08 6.99e-11 1.62e-08 1570.0 4380.0 7700.0 374.0 1440.0 2000.0 569.0 2190.0 5470.0 49 175 225 573 1.27e+03 2.07e+03 2.75e+03 0.0 strong weak moderate weak weak moderate moderate 6.31 6.23 5.95 6.32 5.04 5.12 5.31 6.31 96.2 1.36 E654A|R408G 1.5mg/kg: 9120.49 25.15 1.33 0.93 1.85 2.26 6.65 53 46 569 10 100 92 87 A
85 IgG1 3a 2.59e-09 8.04e-10 1.51e-07 2.71e-10 1.25e-07 >25000 >25000 >25000 >25000 >25000 >25000 284 786 429 1762 9.62e+03 3.59e+04 7.77e+04 strong moderate moderate weak weak moderate moderate 6.07 6.09 5.73 6.12 4.79 4.63 5.28 6.06 93.2 3.81 44.55 2.35 1.95 3.90 1.45 4.26 57 96 25000 58 100 100 100 A
86 IgG1 2.16e-09 4.41e-10 1.03e-07 3.15e-10 1.03e-07 6150.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 691 4356 1.68e+04 4.58e+04 8.24e+04 moderate moderate moderate weak weak moderate moderate 6.21 6.18 5.92 6.3 5.38 5.42 5.32 6.39 96.8 2.05 36.45 1.92 2.13 4.26 1.18 3.46 65 94 25000 62 90 100 96 A
87 IgG4 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.0 3.79 3.62 3.71 3.46 3.9 4.91 4.65 8.2 1.22 30.20 1.59 1.80 3.60 1.15 3.38
88 IgG1
89 IgG1 1 1.22e-09 5.64e-10 6.73e-08 1.49e-10 2.81e-09 536.0 2130.0 4470.0 412.0 1450.0 2380.0 82.5 406.0 >25000 417 1117 4.46e+03 2.17e+04 5.46e+04 0.0 weak moderate weak weak weak moderate moderate 6.07 6.24 5.73 5.62 5.42 3.93 4.13 5.21 60.9 1.44 1.5mg/kg: 114.40 31.75 1.68 1.60 3.20 1.72 5.06 nt nt nt nt nt nt nt
90 IgG1 2c 2.93e-10 1.27e-10 1.1e-07 1.86e-09 380.0 1190.0 2110.0 1040.0 1520.0 1670.0 >25000 >25000 >25000 218 1357 1.89e+03 4.31e+03 6.98e+03 moderate weak moderate strong weak moderate moderate 6.33 6.26 5.97 6.38 5.53 5.74 5.59 6.49 100.0 1.57 26.25 1.39 1.67 3.34 0.80 2.35 32 100 25000 68 100 100 100 H3
91 IgG1 4c 2.43e-10 5.69e-10 4.69e-09 4.46e-06 6.46e-10 3.48e-09 327.0 1660.0 4940.0 814.0 1220.0 1350.0 >25000 >25000 >25000 66 680 4846 10146 2.50e+04 2.50e+04 2.50e+04 None strong weak strong strong moderate moderate moderate 6.26 6.23 5.91 6.34 5.48 5.57 5.53 6.39 21.7 3.92 0.5mg/kg: 1375.38 49.40 2.61 1.06 2.13 1.41 4.13 61 100 25000 80 76 90 90 G
92 IgG1 2c 1.04e-09 5.73e-10 1.96e-07 208.0 521.0 918.0 >25000 >25000 >25000 >25000 >25000 >25000 144 368 5.92e+02 1.03e+03 1.43e+03 strong moderate moderate moderate weak moderate moderate 6.12 6.08 5.8 6.18 3.8 5.13 5.23 6.17 91.2 1.49 51.95 2.74 1.33 2.66 1.75 5.15 26 100 25000 78 97 100 100
93 IgG2 1 1.02e-10 2.7e-11 4.31e-10 6.52e-07 2.02e-11 5.53e-10 69.3 225.0 407.0 26.9 89.8 199.0 26.2 70.1 138.0 >25000 >25000 7.05e+01 9.92e+01 1.21e+02 0.0 moderate weak strong strong weak moderate moderate 6.37 6.32 5.99 3.8 5.77 4.36 4.73 4.56 95.4 1.43 R685S 0.5mg/kg: 66.10|1.5mg/kg: 295.85 24.60 1.30 1.50 3.00 0.62 1.82 3 4 26.2 1 2 2 1 B
94 IgG1 4a 1.04e-10 1.1e-10 5.62e-09 4.35e-11 2.77e-11 35.2 96.8 167.0 16.2 42.7 73.1 >25000 >25000 >25000 4 8 2 6 8.87e+01 1.38e+02 1.79e+02 90.0 moderate moderate