CC12.3 |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5035 |
16232 |
|
|
|
|
54.642857142857146 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1.4 |
|
|
|
|
|
|
|
|
|
|
|
Untreated Infected Control |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mock Infected Control |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
mAb-251 |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CR3022 |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
moderate |
weak |
weak |
moderate |
weak |
strong |
strong |
5.99 |
6.11 |
4.78 |
5.73 |
3.94 |
5.12 |
5.3 |
6.16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
KZ52 |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
weak |
moderate |
weak |
strong |
weak |
weak |
weak |
4.06 |
3.84 |
4.38 |
3.7 |
3.78 |
3.59 |
4.4 |
4.29 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
negative plasma |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
weak |
moderate |
weak |
weak |
strong |
weak |
weak |
4.01 |
3.79 |
4.33 |
3.7 |
3.76 |
3.58 |
4.33 |
4.2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CC12.14 |
|
|
None |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1299 |
4989 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2.1 |
|
|
|
|
|
|
|
|
|
|
|
1 |
|
|
IgG1 |
1 |
1.63e-09 |
1.75e-10 |
1.46e-06 |
|
4.19e-08 |
|
1830.0 |
6370.0 |
14100.0 |
2430.0 |
2510.0 |
2530.0 |
202.0 |
>25000 |
>25000 |
245 |
662 |
|
|
|
1.24e+03 |
1.65e+03 |
1.95e+03 |
|
|
weak |
moderate |
weak |
strong |
moderate |
weak |
moderate |
6.09 |
6.05 |
5.48 |
4.83 |
3.5 |
3.93 |
4.87 |
5.66 |
69.6 |
|
|
|
|
1.2 |
|
|
|
|
20.50 |
0.90 |
1.32 |
1.02 |
0.05 |
0.06 |
|
2 |
|
|
IgG1 |
2b |
1.24e-10 |
5.16e-11 |
1.23e-07 |
|
1.33e-11 |
|
1470.0 |
4010.0 |
7910.0 |
20.6 |
89.3 |
209.0 |
>25000 |
>25000 |
>25000 |
19 |
60 |
|
|
|
3.03e+02 |
4.69e+02 |
6.05e+02 |
10.0 |
|
strong |
strong |
strong |
strong |
moderate |
moderate |
moderate |
6.34 |
6.28 |
6.01 |
6.42 |
5.65 |
5.96 |
5.89 |
6.63 |
100.0 |
|
|
|
|
2.0 |
Y489H |
|
0.5mg/kg: 2065.60|1.5mg/kg: 7474.30 |
|
30.10 |
1.31 |
1.20 |
0.92 |
0.73 |
0.85 |
|
3 |
|
|
IgG1 |
2c |
1.47e-09 |
8.3e-10 |
8.93e-07 |
|
|
|
2320.0 |
8360.0 |
16000.0 |
705.0 |
2850.0 |
4420.0 |
>25000 |
>25000 |
>25000 |
846 |
2766 |
|
|
|
3.20e+03 |
6.50e+03 |
9.84e+03 |
0.0 |
|
weak |
weak |
weak |
strong |
weak |
moderate |
moderate |
5.87 |
5.99 |
5.0 |
4.39 |
3.63 |
3.94 |
4.68 |
5.03 |
90.3 |
|
|
|
|
1.12 |
|
|
1.5mg/kg: 1527.28 |
|
13.15 |
0.57 |
0.77 |
0.59 |
0.42 |
0.49 |
|
4 |
|
|
IgG1 |
2d |
2.43e-10 |
8.05e-11 |
1.11e-07 |
|
1.84e-08 |
|
709.0 |
2480.0 |
5020.0 |
1530.0 |
1560.0 |
1570.0 |
759.0 |
5560.0 |
>25000 |
179 |
450 |
|
|
|
1.49e+03 |
2.73e+03 |
3.88e+03 |
|
|
moderate |
weak |
weak |
strong |
weak |
moderate |
weak |
6.21 |
6.23 |
5.66 |
5.54 |
4.92 |
3.95 |
4.76 |
5.47 |
100.0 |
|
|
|
|
1.07 |
|
|
|
|
27.90 |
1.22 |
1.17 |
0.90 |
0.52 |
0.60 |
|
5 |
|
|
IgG1 |
2c |
1.08e-09 |
8.64e-10 |
3.98e-07 |
|
|
|
853.0 |
2600.0 |
5260.0 |
29.8 |
186.0 |
406.0 |
158.0 |
415.0 |
679.0 |
433 |
754 |
|
|
|
1.57e+04 |
1.84e+04 |
2.02e+04 |
0.0 |
|
weak |
weak |
weak |
moderate |
weak |
moderate |
moderate |
6.05 |
6.08 |
5.36 |
5.14 |
4.56 |
3.94 |
4.77 |
5.14 |
98.2 |
|
|
|
|
1.23 |
|
|
1.5mg/kg: 1243.76 |
|
15.65 |
0.68 |
1.36 |
1.05 |
0.04 |
0.05 |
|
6 |
|
|
IgG1 |
2a |
5.53e-10 |
3.53e-10 |
8.71e-08 |
|
5.98e-10 |
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
21.4 |
102.0 |
249.0 |
11861 |
22679 |
|
|
|
2.52e+02 |
4.86e+02 |
7.14e+02 |
|
|
moderate |
moderate |
weak |
weak |
moderate |
moderate |
weak |
6.05 |
5.94 |
5.65 |
5.87 |
4.09 |
4.59 |
5.11 |
5.91 |
99.0 |
|
|
|
|
1.28 |
|
|
|
|
22.65 |
0.99 |
1.34 |
1.03 |
0.89 |
1.03 |
|
7 |
|
|
IgG1 |
6b |
1.21e-10 |
3.66e-11 |
1.72e-08 |
4.5e-06 |
4.92e-09 |
|
53.8 |
146.0 |
261.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
18 |
33 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
10.0 |
|
moderate |
moderate |
moderate |
moderate |
weak |
moderate |
weak |
6.09 |
6.0 |
5.71 |
5.98 |
4.58 |
4.57 |
4.92 |
6.15 |
100.0 |
|
|
|
|
2.51 |
|
|
0.5mg/kg: 1789.63|1.5mg/kg: 7481.71 |
|
21.40 |
0.93 |
1.57 |
1.21 |
0.07 |
0.08 |
|
8 |
|
|
IgG1 |
6b |
6.75e-10 |
4.51e-10 |
2.36e-08 |
|
1.34e-10 |
|
12800.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
2191 |
6355 |
|
|
|
1.02e+04 |
1.13e+04 |
1.21e+04 |
|
|
moderate |
weak |
moderate |
weak |
weak |
moderate |
weak |
6.34 |
6.28 |
6.01 |
6.38 |
5.35 |
5.49 |
5.22 |
6.41 |
98.0 |
|
|
|
|
2.85 |
|
|
|
|
22.90 |
1.00 |
1.62 |
1.25 |
0.03 |
0.03 |
|
9 |
|
|
IgG1 |
2c |
1.65e-11 |
7.06e-12 |
2.33e-10 |
9.29e-08 |
3.63e-11 |
2.13e-08 |
12.6 |
24.0 |
34.1 |
>25000 |
>25000 |
>25000 |
1140.0 |
1170.0 |
1170.0 |
<0.32 |
0.54 |
3035 |
4766 |
|
4.83e+00 |
8.61e+00 |
1.21e+01 |
None |
|
weak |
weak |
weak |
moderate |
weak |
moderate |
weak |
3.75 |
3.75 |
3.67 |
3.72 |
3.45 |
3.87 |
4.18 |
4.64 |
100.0 |
|
|
|
|
1.96 |
|
|
0.5mg/kg: 2099.34 |
|
23.45 |
1.02 |
1.18 |
0.90 |
0.14 |
0.17 |
|
10 |
|
|
IgG1 |
2c |
1.84e-11 |
8.3e-12 |
2.04e-10 |
8.55e-08 |
3.92e-11 |
3.14e-08 |
10.1 |
21.2 |
32.7 |
464.0 |
2300.0 |
7470.0 |
51.2 |
325.0 |
907.0 |
<0.32 |
1 |
5862 |
15389 |
|
1.18e+01 |
2.19e+01 |
3.15e+01 |
None |
|
weak |
weak |
weak |
weak |
weak |
weak |
weak |
3.78 |
3.74 |
3.7 |
3.71 |
3.46 |
3.86 |
4.26 |
4.24 |
100.0 |
|
|
|
|
1.29 |
|
|
0.5mg/kg: 3133.56 |
|
21.10 |
0.92 |
1.36 |
1.05 |
0.12 |
0.13 |
|
11 |
|
|
IgG1 |
2c |
2.35e-11 |
9.87e-12 |
2.11e-10 |
4.67e-08 |
2.81e-11 |
4.85e-09 |
6.09 |
16.2 |
28.0 |
>25000 |
>25000 |
>25000 |
159.0 |
656.0 |
1520.0 |
<0.32 |
0.93 |
137 |
196 |
|
1.78e+01 |
2.62e+01 |
3.28e+01 |
90.0 |
|
weak |
moderate |
weak |
moderate |
weak |
moderate |
weak |
3.86 |
3.77 |
3.74 |
3.69 |
3.45 |
3.89 |
4.09 |
4.16 |
99.4 |
|
|
|
|
0.893 |
|
|
0.5mg/kg: 2060.71|1.5mg/kg: 8050.89 |
|
34.05 |
1.49 |
1.30 |
1.00 |
1.01 |
1.18 |
|
12 |
|
|
IgG1 |
2c |
1.11e-11 |
5.07e-12 |
1.64e-10 |
7.55e-08 |
4.24e-11 |
3.66e-08 |
7.48 |
18.6 |
30.6 |
990.0 |
1190.0 |
1250.0 |
352.0 |
1050.0 |
1450.0 |
<0.32 |
<0.32 |
2526 |
4536 |
|
8.62e+00 |
1.43e+01 |
1.93e+01 |
None |
|
weak |
strong |
weak |
strong |
weak |
moderate |
weak |
3.67 |
3.75 |
3.62 |
3.71 |
3.45 |
3.88 |
4.14 |
4.2 |
100.0 |
|
|
|
|
2.42 |
|
|
0.5mg/kg: 2732.99 |
|
21.50 |
0.94 |
1.41 |
1.08 |
0.05 |
0.06 |
|
13 |
|
|
IgG1 |
2c |
8.95e-12 |
4.71e-12 |
1.16e-10 |
5.11e-08 |
2.42e-11 |
|
6.07 |
15.4 |
25.3 |
71.7 |
235.0 |
459.0 |
19.4 |
54.8 |
97.5 |
<0.32 |
0.85 |
159 |
627 |
|
4.75e+00 |
7.05e+00 |
8.88e+00 |
70.0 |
|
weak |
weak |
weak |
strong |
weak |
moderate |
moderate |
4.04 |
4.43 |
3.8 |
3.72 |
3.48 |
3.91 |
4.82 |
4.76 |
100.0 |
|
|
|
|
3.3 |
|
|
0.5mg/kg: 4115.36|1.5mg/kg: 10520.90 |
|
9.65 |
0.42 |
2.07 |
1.59 |
0.47 |
0.55 |
|
14 |
|
|
IgG1 |
2d |
4.43e-11 |
1.1e-11 |
1.94e-09 |
1.14e-06 |
5.3e-11 |
5.45e-08 |
9.75 |
24.7 |
42.9 |
>25000 |
>25000 |
>25000 |
373.0 |
1490.0 |
7440.0 |
<0.32 |
<0.32 |
>12500 |
>12500 |
|
6.70e-01 |
1.42e+00 |
2.21e+00 |
|
|
strong |
strong |
strong |
strong |
moderate |
moderate |
strong |
6.37 |
6.32 |
6.02 |
6.46 |
5.71 |
5.99 |
5.74 |
6.6 |
100.0 |
|
|
|
|
3.49 |
|
|
|
|
30.05 |
1.31 |
0.97 |
0.75 |
0.76 |
0.88 |
|
15 |
|
|
IgG1 |
2d |
9.47e-11 |
4.56e-11 |
1.19e-08 |
1.19e-07 |
1.22e-09 |
2.88e-09 |
32.0 |
107.0 |
223.0 |
>25000 |
>25000 |
>25000 |
1610.0 |
3140.0 |
3780.0 |
1 |
10 |
>12500 |
>12500 |
|
3.12e+01 |
4.93e+01 |
6.44e+01 |
|
|
strong |
strong |
strong |
strong |
strong |
moderate |
moderate |
6.38 |
6.33 |
6.04 |
6.45 |
5.74 |
6.08 |
5.86 |
6.63 |
100.0 |
|
|
|
|
3.63 |
|
|
|
|
22.45 |
0.98 |
1.43 |
1.10 |
0.07 |
0.09 |
|
16 |
|
|
IgG1 |
2a |
1.57e-10 |
5.04e-11 |
5.31e-09 |
1.03e-06 |
7.34e-10 |
9.66e-09 |
44.5 |
180.0 |
388.0 |
995.0 |
>25000 |
>25000 |
215.0 |
888.0 |
1380.0 |
10518 |
>25000 |
|
|
|
1.61e+04 |
8.58e+04 |
2.28e+05 |
|
|
moderate |
weak |
weak |
strong |
weak |
moderate |
moderate |
6.15 |
6.15 |
5.36 |
3.9 |
5.09 |
3.94 |
4.91 |
5.04 |
100.0 |
|
|
|
|
1.54 |
|
|
|
|
|
|
|
|
|
|
|
17 |
|
|
IgG1 |
4b |
5.04e-10 |
4.01e-10 |
3.46e-08 |
|
1.81e-10 |
2.82e-09 |
1030.0 |
3020.0 |
5630.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
8726 |
24853 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
strong |
moderate |
moderate |
moderate |
moderate |
moderate |
moderate |
6.33 |
6.28 |
5.99 |
6.4 |
5.49 |
5.67 |
5.66 |
6.51 |
67.0 |
|
|
|
|
5.79 |
|
|
|
|
20.55 |
0.90 |
1.44 |
1.10 |
0.09 |
0.10 |
|
18 |
|
|
IgG |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19 |
|
|
IgG |
|
1.08e-09 |
1.18e-09 |
2.64e-08 |
|
|
|
39.7 |
140.0 |
262.0 |
664.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
433 |
1516 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
weak |
weak |
moderate |
weak |
moderate |
weak |
4.07 |
3.8 |
3.83 |
3.73 |
3.45 |
3.93 |
4.75 |
4.54 |
23.7 |
|
|
|
|
1.42 |
|
|
|
|
|
|
|
|
|
|
|
20 |
|
|
IgG1 |
|
7.59e-10 |
8.13e-10 |
|
8.15e-08 |
1.36e-09 |
2.32e-09 |
72.3 |
587.0 |
>25000 |
639.0 |
1160.0 |
1350.0 |
>25000 |
>25000 |
>25000 |
236 |
4924 |
|
|
|
2.59e+03 |
9.47e+03 |
2.02e+04 |
10.0 |
|
strong |
moderate |
moderate |
strong |
strong |
moderate |
strong |
6.09 |
6.0 |
5.77 |
6.02 |
4.23 |
4.57 |
5.23 |
6.07 |
9.0 |
|
|
|
|
3.64 |
|
|
0.5mg/kg: 50.30|1.5mg/kg: 58.71 |
|
24.15 |
1.05 |
1.61 |
1.24 |
0.14 |
0.16 |
|
21 |
|
|
IgG1 |
7c |
5.02e-10 |
1.4e-09 |
2.08e-10 |
|
5.25e-10 |
9.26e-09 |
12500.0 |
>25000 |
>25000 |
162.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
8582 |
20807 |
|
|
|
1.99e+04 |
3.48e+04 |
4.82e+04 |
0.0 |
|
strong |
moderate |
moderate |
moderate |
moderate |
moderate |
weak |
6.29 |
6.22 |
5.95 |
6.3 |
5.2 |
5.14 |
5.34 |
6.28 |
11.6 |
|
|
|
|
2.69 |
|
|
0.5mg/kg: 134.98|1.5mg/kg: 643.01 |
|
40.20 |
1.76 |
2.06 |
1.58 |
0.51 |
0.59 |
|
22 |
|
|
IgG1 |
6a |
1.08e-09 |
3e-09 |
1.04e-07 |
|
3.68e-10 |
1.84e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
weak |
moderate |
weak |
weak |
moderate |
weak |
6.24 |
6.2 |
5.89 |
6.22 |
5.0 |
4.63 |
5.2 |
6.11 |
51.1 |
|
|
|
|
2.95 |
|
|
1.5mg/kg: 1601.37 |
|
12.20 |
0.53 |
6.80 |
5.23 |
0.73 |
0.85 |
|
23 |
|
|
IgG1 |
5b |
3.72e-10 |
5.86e-10 |
7.13e-08 |
|
2e-10 |
4.25e-09 |
14200.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
moderate |
moderate |
weak |
moderate |
moderate |
weak |
6.27 |
6.22 |
5.93 |
6.27 |
4.82 |
5.04 |
5.09 |
6.27 |
36.3 |
|
|
|
|
5.49 |
|
|
1.5mg/kg: 158.53 |
|
18.15 |
0.79 |
1.63 |
1.25 |
0.12 |
0.13 |
|
24 |
|
|
IgG1 |
7b |
1.21e-09 |
2.3e-09 |
1.46e-08 |
|
7.49e-10 |
2.55e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
14175 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
moderate |
strong |
weak |
weak |
weak |
strong |
moderate |
6.22 |
6.18 |
5.86 |
6.23 |
5.08 |
4.78 |
5.17 |
6.21 |
48.7 |
|
|
|
|
3.48 |
|
|
1.5mg/kg: 3119.58 |
|
33.00 |
1.44 |
0.84 |
0.65 |
1.14 |
1.33 |
|
25 |
|
|
IgG1 |
7b |
1.07e-09 |
1.9e-09 |
8.49e-08 |
|
6.96e-09 |
8.2e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
moderate |
moderate |
strong |
moderate |
weak |
moderate |
moderate |
5.77 |
5.93 |
5.07 |
5.59 |
3.78 |
4.02 |
4.91 |
5.71 |
31.2 |
|
|
|
|
2.47 |
|
|
|
|
21.40 |
1.15 |
1.68 |
5.00 |
0.63 |
1.05 |
|
26 |
|
|
IgG1 |
7b |
6.57e-10 |
1.18e-09 |
3.88e-08 |
|
5.36e-09 |
|
|
|
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.22 |
6.14 |
5.81 |
6.16 |
4.75 |
4.54 |
5.25 |
6.14 |
31.8 |
|
|
|
|
5.8 |
|
|
1.5mg/kg: 630.67 |
|
19.20 |
1.04 |
0.84 |
2.52 |
0.46 |
0.76 |
|
27 |
|
|
IgG1 |
3a |
3.59e-09 |
1.42e-09 |
1.48e-07 |
|
2.62e-10 |
8.91e-08 |
8250.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
260 |
2457 |
1173 |
4632 |
|
2.07e+04 |
3.24e+04 |
4.22e+04 |
|
|
strong |
moderate |
moderate |
strong |
weak |
moderate |
moderate |
6.19 |
6.13 |
5.87 |
6.24 |
5.23 |
5.04 |
5.3 |
6.34 |
88.6 |
|
|
|
|
6.13 |
|
|
|
|
24.55 |
1.32 |
1.69 |
5.04 |
0.61 |
1.02 |
|
28 |
|
|
IgG1 |
6b |
3.3e-10 |
5.22e-10 |
1.23e-08 |
|
1.26e-10 |
2.32e-08 |
512.0 |
1960.0 |
3960.0 |
755.0 |
1400.0 |
1760.0 |
308.0 |
>25000 |
>25000 |
190 |
815 |
398 |
897 |
|
3.19e+03 |
4.68e+03 |
5.85e+03 |
0.0 |
|
strong |
moderate |
moderate |
strong |
weak |
moderate |
moderate |
6.36 |
6.3 |
6.02 |
6.42 |
5.63 |
5.9 |
5.61 |
6.55 |
100.0 |
|
|
|
|
6.13 |
|
|
0.5mg/kg: 1908.96|1.5mg/kg: 3954.73 |
|
27.10 |
1.46 |
1.84 |
5.49 |
0.67 |
1.12 |
|
29 |
|
|
IgG1 |
|
4.33e-10 |
3.5e-10 |
|
3.99e-07 |
|
|
|
|
|
1020.0 |
1520.0 |
1750.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
moderate |
weak |
weak |
strong |
weak |
moderate |
weak |
6.24 |
6.18 |
5.89 |
6.2 |
4.64 |
4.74 |
5.15 |
6.16 |
|
|
|
|
|
5.0 |
|
|
|
|
19.25 |
1.04 |
0.77 |
2.28 |
0.68 |
1.13 |
|
30 |
|
|
IgG1 |
2d |
3.21e-11 |
5.94e-12 |
4.1e-09 |
2.73e-06 |
|
|
8.87 |
26.8 |
50.7 |
518.0 |
1650.0 |
>25000 |
47.1 |
113.0 |
200.0 |
2 |
6 |
>25000 |
>25000 |
|
2.75e+01 |
5.23e+01 |
7.61e+01 |
100.0 |
|
strong |
strong |
strong |
moderate |
moderate |
moderate |
moderate |
6.36 |
6.3 |
6.02 |
6.45 |
5.72 |
6.06 |
5.53 |
6.59 |
100.0 |
|
|
|
|
7.37 |
E484A |
|
0.5mg/kg: 2456.41|1.5mg/kg: 8195.59 |
|
25.45 |
1.37 |
1.31 |
3.91 |
0.59 |
0.99 |
|
31 |
|
|
IgG1 |
4b |
1.42e-10 |
8.08e-11 |
7.02e-08 |
|
3.96e-10 |
|
11400.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
949 |
2233 |
|
|
|
1.21e+04 |
4.33e+04 |
9.12e+04 |
10.0 |
|
strong |
weak |
moderate |
moderate |
moderate |
moderate |
moderate |
6.3 |
6.26 |
5.97 |
6.4 |
5.68 |
6.03 |
5.67 |
6.6 |
99.0 |
|
|
|
|
2.57 |
|
|
1.5mg/kg: 2850.55 |
|
24.85 |
1.34 |
0.96 |
2.87 |
0.80 |
1.33 |
|
32 |
|
|
IgG1 |
2d |
5.76e-11 |
1.85e-11 |
1.76e-09 |
1.96e-06 |
2.04e-10 |
|
8.66 |
32.3 |
66.4 |
>25000 |
>25000 |
>25000 |
1.08 |
1.06 |
1.06 |
2 |
8 |
735 |
2676 |
|
6.11e+01 |
1.44e+02 |
2.37e+02 |
60.0 |
|
strong |
strong |
strong |
moderate |
moderate |
moderate |
weak |
6.39 |
6.32 |
6.05 |
6.46 |
5.72 |
6.08 |
5.68 |
6.61 |
100.0 |
|
|
|
|
2.65 |
G496V|S494L |
|
0.5mg/kg: 3150.21|1.5mg/kg: 6774.03 |
|
26.20 |
1.41 |
0.74 |
2.22 |
0.78 |
1.29 |
|
33 |
|
|
IgG1 |
|
3.32e-08 |
1.63e-08 |
|
4.8e-06 |
|
8.18e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
5650.0 |
7400.0 |
7930.0 |
18 |
44 |
259 |
637 |
|
4.57e+03 |
6.06e+03 |
7.14e+03 |
10.0 |
|
strong |
weak |
weak |
weak |
weak |
moderate |
moderate |
4.35 |
4.01 |
3.81 |
3.77 |
3.48 |
3.94 |
4.91 |
5.23 |
7.6 |
|
|
|
|
3.29 |
|
|
|
|
24.30 |
1.31 |
0.56 |
1.67 |
0.91 |
1.52 |
|
34 |
|
|
IgG1 |
|
2.37e-09 |
1.74e-09 |
|
|
3.92e-09 |
5.29e-08 |
162.0 |
453.0 |
1050.0 |
1.13 |
1.12 |
1.12 |
>25000 |
>25000 |
>25000 |
201 |
19356 |
|
|
|
1.02e+04 |
2.14e+04 |
3.30e+04 |
0.0 |
|
moderate |
moderate |
weak |
weak |
weak |
moderate |
strong |
6.0 |
5.97 |
5.52 |
5.7 |
4.31 |
4.12 |
5.01 |
5.71 |
6.4 |
|
|
|
|
2.3 |
|
|
1.5mg/kg: 50.30 |
|
19.80 |
1.07 |
0.84 |
2.51 |
0.94 |
1.57 |
|
35 |
|
|
IgG1 |
7c |
1.68e-09 |
1.05e-09 |
2.81e-09 |
|
4.34e-10 |
2.3e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
strong |
moderate |
weak |
weak |
moderate |
weak |
6.21 |
6.2 |
5.9 |
6.25 |
5.33 |
5.21 |
5.31 |
6.22 |
7.1 |
|
|
|
|
3.24 |
|
|
1.5mg/kg: 1842.61 |
|
24.50 |
1.32 |
0.76 |
2.25 |
0.59 |
0.99 |
|
36 |
|
|
IgG1 |
|
4.36e-09 |
4.96e-09 |
|
9.51e-07 |
|
|
86.2 |
6600.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
4 |
14 |
>25000 |
>25000 |
|
3.07e+01 |
1.18e+02 |
2.59e+02 |
60.0 |
|
moderate |
moderate |
weak |
weak |
weak |
moderate |
weak |
6.18 |
6.11 |
5.87 |
6.18 |
5.04 |
5.07 |
5.06 |
6.21 |
|
|
|
|
|
3.1 |
del68-70 |
|
0.5mg/kg: 63.45 |
|
23.85 |
1.29 |
0.61 |
1.82 |
0.15 |
0.25 |
|
37 |
|
|
IgG1 |
|
1.9e-08 |
3.96e-08 |
|
|
|
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
moderate |
moderate |
weak |
weak |
weak |
moderate |
weak |
5.19 |
5.28 |
4.44 |
4.15 |
3.53 |
3.92 |
4.86 |
5.2 |
3.9 |
|
|
|
|
0.459 |
|
|
|
|
22.15 |
1.19 |
0.64 |
1.91 |
1.16 |
1.93 |
|
38 |
|
|
IgG |
6b |
1.09e-09 |
4.54e-10 |
7.05e-09 |
|
1.4e-10 |
|
297.0 |
1310.0 |
2900.0 |
863.0 |
2170.0 |
2740.0 |
376.0 |
1820.0 |
2920.0 |
16 |
78 |
41 |
123 |
|
3.45e+02 |
7.16e+02 |
1.10e+03 |
None |
|
moderate |
moderate |
moderate |
strong |
moderate |
moderate |
strong |
6.35 |
6.3 |
6.01 |
6.42 |
5.52 |
5.76 |
5.48 |
6.45 |
99.3 |
|
|
|
|
1.05 |
|
|
0.5mg/kg: 176.64 |
|
21.40 |
1.15 |
0.59 |
1.76 |
0.54 |
0.90 |
|
39 |
|
|
IgG |
2d |
3.12e-11 |
1.06e-11 |
1.78e-09 |
1.66e-06 |
3.33e-08 |
4.13e-08 |
7.11 |
20.1 |
35.8 |
>25000 |
>25000 |
>25000 |
124.0 |
333.0 |
750.0 |
<0.32 |
<0.32 |
12500 |
12500 |
|
1.66e+01 |
2.68e+01 |
3.56e+01 |
None |
|
strong |
strong |
strong |
strong |
moderate |
moderate |
moderate |
6.36 |
6.32 |
6.03 |
6.47 |
5.71 |
6.01 |
5.7 |
6.61 |
100.0 |
|
|
|
|
1.47 |
L452P |
|
0.5mg/kg: 3296.86 |
|
24.60 |
1.33 |
0.98 |
2.94 |
0.86 |
1.43 |
|
40 |
|
|
IgG |
2d |
7.15e-11 |
3.82e-11 |
1.68e-08 |
|
6.92e-09 |
4.03e-08 |
248.0 |
825.0 |
1590.0 |
>25000 |
>25000 |
>25000 |
289.0 |
1540.0 |
3400.0 |
76 |
216 |
>25000 |
>25000 |
|
4.76e+02 |
1.46e+03 |
2.80e+03 |
None |
|
strong |
moderate |
strong |
strong |
weak |
moderate |
moderate |
6.37 |
6.31 |
6.03 |
6.45 |
5.71 |
6.06 |
5.82 |
6.63 |
100.0 |
|
|
|
|
0.868 |
F490C|F490L|F490V |
|
0.5mg/kg: 1926.61 |
|
18.80 |
1.01 |
0.47 |
1.42 |
0.91 |
1.52 |
|
41 |
|
|
IgG1 |
|
2.33e-10 |
2.49e-10 |
|
2.75e-08 |
1.06e-10 |
7.77e-10 |
6450.0 |
23200.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
5997 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
100.0 |
|
strong |
weak |
moderate |
moderate |
weak |
moderate |
weak |
6.3 |
6.25 |
5.95 |
6.35 |
5.51 |
5.6 |
4.6 |
6.36 |
|
|
|
|
|
1.02 |
|
|
1.5mg/kg: 15897.03 |
|
23.00 |
1.24 |
0.66 |
1.97 |
1.05 |
1.76 |
|
42 |
|
|
IgG1 |
2a |
4.84e-10 |
1.59e-10 |
1.1e-08 |
|
4.47e-10 |
|
57.6 |
185.0 |
348.0 |
1000.0 |
21700.0 |
>25000 |
13.8 |
53.8 |
124.0 |
14 |
44 |
2246 |
6637 |
|
7.81e+02 |
1.81e+03 |
2.95e+03 |
0.0 |
|
strong |
moderate |
strong |
moderate |
moderate |
moderate |
moderate |
6.37 |
6.3 |
6.02 |
6.45 |
5.61 |
5.87 |
5.44 |
6.56 |
98.8 |
|
|
|
|
0.626 |
|
|
0.5mg/kg: 3894.89 |
|
21.45 |
1.16 |
0.41 |
1.22 |
0.40 |
0.67 |
|
43 |
|
|
IgG4 |
2c |
1.94e-10 |
9.59e-11 |
2.27e-08 |
|
1.48e-08 |
|
34.1 |
109.0 |
210.0 |
>25000 |
>25000 |
>25000 |
3.2 |
17.5 |
47.5 |
13 |
31 |
1672 |
3234 |
|
1.22e+03 |
2.06e+03 |
2.81e+03 |
10.0 |
|
strong |
weak |
moderate |
weak |
weak |
moderate |
moderate |
6.38 |
6.11 |
6.01 |
3.8 |
5.72 |
4.02 |
4.25 |
4.98 |
100.0 |
|
|
|
|
0.718 |
|
|
0.5mg/kg: 206.34|1.5mg/kg: 778.93 |
|
22.20 |
1.20 |
0.82 |
2.46 |
0.83 |
1.39 |
|
44 |
|
|
IgG1 |
2c |
1.42e-10 |
1.98e-10 |
4.74e-08 |
|
|
|
53.4 |
163.0 |
302.0 |
>25000 |
>25000 |
>25000 |
102.0 |
265.0 |
432.0 |
5 |
19 |
>25000 |
>25000 |
|
4.26e+02 |
1.01e+03 |
1.66e+03 |
30.0 |
|
strong |
moderate |
moderate |
moderate |
weak |
moderate |
weak |
6.3 |
6.24 |
5.98 |
6.4 |
5.61 |
5.94 |
5.57 |
6.53 |
100.0 |
|
|
|
|
1.41 |
|
|
1.5mg/kg: 1312.88 |
|
24.15 |
1.30 |
0.78 |
2.31 |
0.80 |
1.33 |
|
45 |
|
|
IgG4 |
2c |
1.7e-10 |
3.6e-11 |
3.67e-08 |
|
|
|
8.06 |
27.7 |
55.2 |
>25000 |
>25000 |
>25000 |
5.47 |
28.6 |
68.7 |
2 |
8 |
>25000 |
>25000 |
|
1.04e+02 |
1.56e+02 |
1.98e+02 |
30.0 |
|
moderate |
weak |
moderate |
weak |
weak |
moderate |
weak |
6.37 |
6.2 |
6.02 |
3.82 |
5.69 |
4.03 |
4.29 |
5.44 |
100.0 |
|
|
|
|
1.85 |
|
|
0.5mg/kg: 372.94|1.5mg/kg: 1152.88 |
|
18.90 |
1.02 |
0.66 |
1.96 |
0.72 |
1.20 |
|
46 |
|
|
IgG1 |
|
|
2.98e-09 |
|
|
|
3.14e-08 |
|
|
|
>25000 |
>25000 |
>25000 |
2230.0 |
3430.0 |
3800.0 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
4.14 |
3.92 |
3.84 |
3.72 |
3.5 |
3.9 |
4.85 |
5.39 |
6.5 |
|
|
|
|
1.23 |
|
|
|
|
35.20 |
1.90 |
0.76 |
2.27 |
0.63 |
1.05 |
|
47 |
|
|
IgG4 |
|
2.73e-09 |
3.18e-09 |
|
|
|
3.55e-08 |
4610.0 |
11000.0 |
18900.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
4.54 |
4.86 |
3.98 |
4.25 |
3.69 |
3.92 |
4.85 |
4.63 |
24.4 |
|
|
|
|
2.53 |
T588A |
|
|
|
23.10 |
1.25 |
0.59 |
1.76 |
0.94 |
1.57 |
|
48 |
|
|
IgG1 |
2a |
4.28e-10 |
1.51e-10 |
1.22e-07 |
|
2.19e-08 |
|
1150.0 |
3620.0 |
13300.0 |
>25000 |
>25000 |
>25000 |
115.0 |
696.0 |
>25000 |
426 |
1028 |
|
|
|
2.82e+03 |
4.63e+03 |
6.18e+03 |
|
|
moderate |
moderate |
weak |
weak |
weak |
moderate |
weak |
6.22 |
6.17 |
5.86 |
6.22 |
4.61 |
4.46 |
5.02 |
6.13 |
100.0 |
|
|
|
|
3.14 |
|
|
|
|
23.35 |
1.26 |
1.07 |
3.19 |
0.52 |
0.86 |
|
49 |
|
|
IgG4 |
2a |
3.41e-10 |
1.36e-10 |
1.48e-07 |
|
1.39e-08 |
|
57.4 |
219.0 |
506.0 |
2540.0 |
3720.0 |
4100.0 |
35.7 |
133.0 |
259.0 |
110 |
256 |
|
|
|
2.24e+03 |
9.30e+03 |
2.14e+04 |
0.0 |
|
moderate |
moderate |
moderate |
weak |
weak |
weak |
weak |
6.13 |
5.75 |
5.88 |
3.74 |
5.57 |
3.98 |
4.58 |
4.61 |
100.0 |
|
|
|
|
2.67 |
|
|
1.5mg/kg: 1233.73 |
|
23.80 |
1.28 |
0.92 |
2.75 |
0.58 |
0.97 |
|
50 |
|
|
IgG1 |
2a |
4.68e-10 |
1.75e-10 |
7.87e-08 |
|
1.89e-08 |
|
869.0 |
3110.0 |
6470.0 |
>25000 |
>25000 |
>25000 |
116.0 |
398.0 |
1480.0 |
70 |
322 |
>25000 |
>25000 |
|
4.58e+03 |
1.11e+04 |
1.87e+04 |
|
|
strong |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.23 |
6.19 |
5.86 |
6.21 |
4.63 |
4.58 |
5.14 |
6.12 |
100.0 |
|
|
|
|
1.27 |
K417E |
|
|
|
25.95 |
1.40 |
0.92 |
2.73 |
0.67 |
1.11 |
|
51 |
|
|
IgG1 |
|
|
|
|
|
|
|
|
|
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
weak |
weak |
strong |
weak |
moderate |
strong |
4.48 |
3.87 |
3.79 |
3.72 |
3.46 |
3.94 |
4.92 |
4.72 |
13.5 |
|
|
|
|
0.716 |
|
|
|
|
25.80 |
1.39 |
1.22 |
3.64 |
0.61 |
1.02 |
|
52 |
|
|
IgG1 |
2a |
2.47e-10 |
1.57e-10 |
1.71e-09 |
|
6.94e-09 |
|
221.0 |
606.0 |
1080.0 |
>25000 |
>25000 |
>25000 |
134.0 |
471.0 |
739.0 |
64 |
187 |
>25000 |
>25000 |
|
6.07e+02 |
1.49e+03 |
2.52e+03 |
0.0 |
|
strong |
moderate |
strong |
strong |
moderate |
moderate |
moderate |
6.36 |
6.29 |
6.02 |
6.44 |
5.65 |
5.87 |
5.41 |
6.56 |
95.0 |
|
|
|
|
1.38 |
Y489H |
|
1.5mg/kg: 4210.07 |
|
24.65 |
1.33 |
1.07 |
3.19 |
0.55 |
0.92 |
|
53 |
|
|
IgG1 |
|
|
|
|
|
6e-10 |
2.37e-08 |
189.0 |
801.0 |
1730.0 |
34.7 |
185.0 |
524.0 |
86.5 |
559.0 |
1130.0 |
95 |
242 |
249 |
800 |
|
5.91e+03 |
9.09e+03 |
1.17e+04 |
0.0 |
|
moderate |
weak |
weak |
strong |
weak |
moderate |
moderate |
5.45 |
5.44 |
4.8 |
4.96 |
3.5 |
3.92 |
4.86 |
5.19 |
70.0 |
|
|
|
|
1.04 |
|
|
1.5mg/kg: 50.30 |
|
22.45 |
1.21 |
1.10 |
3.28 |
0.68 |
1.13 |
|
54 |
|
|
|
7a |
8.65e-10 |
2.44e-09 |
2.44e-07 |
|
8.76e-11 |
1.58e-08 |
37.0 |
87.4 |
139.0 |
26.4 |
68.2 |
111.0 |
12.9 |
37.8 |
64.4 |
6 |
22 |
2 |
6 |
|
2.44e+02 |
3.44e+02 |
4.21e+02 |
|
|
weak |
weak |
weak |
moderate |
weak |
moderate |
weak |
4.19 |
3.75 |
3.86 |
3.74 |
3.47 |
3.9 |
4.94 |
4.6 |
99.5 |
|
|
|
|
0.864 |
S375F|S375F,D1118H |
|
|
|
6.90 |
0.37 |
0.47 |
1.40 |
0.58 |
0.97 |
|
55 |
|
|
IgG1 |
|
1.56e-10 |
5.8e-11 |
1.15e-07 |
|
3.12e-11 |
1.81e-08 |
13.1 |
38.3 |
70.7 |
5.98 |
23.0 |
48.2 |
5.47 |
17.0 |
30.6 |
13 |
27 |
60 |
125 |
|
2.49e+02 |
3.85e+02 |
4.97e+02 |
0.0 |
|
strong |
moderate |
moderate |
strong |
moderate |
moderate |
strong |
6.37 |
6.28 |
6.01 |
6.42 |
5.59 |
5.74 |
5.53 |
6.45 |
100.0 |
|
|
|
|
1.12 |
|
|
1.5mg/kg: 142.39 |
|
24.20 |
1.30 |
0.94 |
2.79 |
1.04 |
1.73 |
|
56 |
|
|
IgG1 |
|
1.13e-10 |
3.82e-11 |
9.42e-08 |
1.64e-05 |
3e-11 |
1.83e-08 |
6.36 |
24.3 |
51.7 |
1.52 |
6.68 |
16.5 |
1.74 |
5.53 |
10.5 |
2 |
7 |
6 |
20 |
|
1.02e+02 |
1.77e+02 |
2.44e+02 |
0.0 |
|
strong |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.33 |
6.23 |
5.96 |
6.34 |
5.41 |
5.27 |
5.34 |
6.32 |
100.0 |
|
|
|
|
1.86 |
|
|
1.5mg/kg: 50.30 |
|
26.50 |
1.43 |
1.19 |
3.54 |
0.51 |
0.85 |
|
57 |
|
|
|
|
1.36e-09 |
2.28e-09 |
2.04e-07 |
|
1.53e-10 |
4.16e-09 |
10.2 |
26.1 |
45.3 |
1.06 |
3.54 |
7.11 |
3.08 |
9.16 |
17.7 |
1 |
5 |
3 |
13 |
|
5.15e+01 |
1.21e+02 |
1.99e+02 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
92.7 |
|
|
|
|
0.66 |
|
|
|
|
19.60 |
1.06 |
1.23 |
3.66 |
0.60 |
1.00 |
|
58 |
|
|
IgG1 |
7a |
2.98e-09 |
9.59e-10 |
1.39e-07 |
|
5.68e-11 |
|
4.6 |
13.6 |
24.7 |
0.805 |
3.1 |
6.51 |
0.45 |
1.74 |
3.19 |
5 |
16 |
14 |
27 |
|
8.74e+01 |
1.11e+02 |
1.27e+02 |
|
|
strong |
moderate |
weak |
strong |
weak |
weak |
weak |
5.29 |
5.52 |
3.75 |
3.65 |
4.13 |
4.15 |
5.41 |
5.29 |
100.0 |
|
|
|
|
2.12 |
|
|
|
|
20.80 |
1.12 |
0.85 |
2.54 |
0.90 |
1.49 |
|
59 |
|
|
|
7a |
4.76e-10 |
1.2e-09 |
2.01e-07 |
|
7.63e-11 |
1.16e-08 |
3.7 |
11.8 |
22.5 |
1.24 |
4.07 |
9.24 |
2.75 |
10.4 |
17.7 |
1 |
1 |
<0.32 |
4 |
|
8.90e+01 |
1.16e+02 |
1.35e+02 |
|
|
weak |
weak |
weak |
weak |
weak |
moderate |
weak |
3.98 |
3.75 |
3.8 |
3.73 |
3.46 |
3.9 |
4.83 |
4.7 |
99.4 |
|
|
|
|
0.957 |
S371F |
|
|
|
21.00 |
1.11 |
1.64 |
3.28 |
0.99 |
2.91 |
|
60 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0.45 |
2 |
0.37 |
2 |
|
1.34e+01 |
2.07e+01 |
2.66e+01 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0.486 |
|
|
|
|
20.20 |
1.07 |
1.34 |
2.69 |
0.55 |
1.62 |
|
61 |
|
|
|
7a |
6.2e-10 |
1.3e-09 |
1.95e-07 |
|
5.25e-11 |
2.04e-09 |
4.96 |
15.8 |
30.8 |
0.886 |
4.0 |
10.2 |
2.28 |
8.63 |
18.5 |
2 |
5 |
<0.32 |
3 |
|
9.05e+01 |
1.32e+02 |
1.65e+02 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
4.04 |
3.78 |
3.78 |
3.7 |
3.46 |
3.91 |
4.9 |
4.86 |
99.5 |
|
|
|
|
0.996 |
D442A |
|
|
|
19.50 |
1.03 |
1.29 |
2.59 |
1.77 |
5.21 |
|
62 |
|
|
IgG1 |
7a |
2.04e-10 |
4.77e-11 |
6.38e-08 |
1.61e-05 |
3.55e-11 |
1.47e-08 |
8.46 |
34.5 |
74.3 |
4.14 |
14.1 |
27.5 |
7.96 |
26.0 |
49.2 |
4 |
8 |
4 |
15 |
|
1.84e+02 |
3.76e+02 |
5.71e+02 |
0.0 |
|
moderate |
strong |
moderate |
strong |
weak |
moderate |
moderate |
6.32 |
6.24 |
5.97 |
6.36 |
5.41 |
5.04 |
5.32 |
6.29 |
100.0 |
|
|
|
|
1.32 |
|
|
1.5mg/kg: 50.63 |
|
23.45 |
1.24 |
1.54 |
3.09 |
0.67 |
1.96 |
|
63 |
|
|
|
7a |
4.52e-10 |
1.07e-09 |
1.85e-07 |
|
6.04e-11 |
4.26e-09 |
2.75 |
10.8 |
23.4 |
>25000 |
>25000 |
>25000 |
4.05 |
11.0 |
19.1 |
<0.32 |
1 |
<0.32 |
0.48 |
|
1.64e+01 |
3.65e+01 |
5.84e+01 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
4.36 |
3.83 |
3.78 |
3.73 |
3.47 |
3.93 |
4.93 |
4.43 |
99.8 |
|
|
|
|
1.35 |
Y508H |
|
|
|
20.85 |
1.10 |
1.25 |
2.50 |
0.51 |
1.50 |
|
64 |
|
|
|
7a |
7.08e-10 |
1.3e-09 |
1.69e-07 |
|
1.34e-10 |
1.85e-08 |
11.6 |
24.6 |
39.2 |
25.5 |
68.3 |
93.9 |
2.53 |
10.3 |
20.1 |
3 |
13 |
<0.32 |
4 |
|
6.20e+01 |
8.84e+01 |
1.09e+02 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
3.94 |
3.8 |
3.82 |
3.73 |
3.46 |
3.92 |
4.86 |
4.41 |
96.6 |
|
|
|
|
1.16 |
del374,Y508H|del374,D571G |
|
|
|
22.40 |
1.18 |
1.49 |
2.98 |
0.62 |
1.84 |
|
65 |
|
|
IgG1 |
7a |
1.01e-10 |
4.01e-11 |
5.1e-08 |
|
2.84e-11 |
1.92e-08 |
10.8 |
29.2 |
51.1 |
1.01 |
5.96 |
11.1 |
3.02 |
10.4 |
21.1 |
16 |
26 |
18 |
36 |
|
2.50e+02 |
4.05e+02 |
5.37e+02 |
|
|
moderate |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.32 |
6.27 |
5.97 |
6.42 |
5.65 |
5.77 |
5.61 |
6.48 |
100.0 |
|
|
|
|
1.72 |
K417E |
|
|
|
21.40 |
1.13 |
1.45 |
2.90 |
0.68 |
1.99 |
|
66 |
|
|
|
|
5.89e-10 |
1.14e-09 |
1.4e-07 |
|
1.29e-10 |
1.88e-08 |
4.17 |
11.0 |
19.5 |
4.47 |
15.2 |
31.9 |
8.61 |
26.7 |
49.6 |
1 |
3 |
<0.32 |
4 |
|
1.12e+02 |
3.10e+02 |
5.62e+02 |
|
|
weak |
weak |
weak |
strong |
weak |
moderate |
strong |
4.28 |
4.07 |
3.88 |
3.85 |
3.47 |
3.9 |
4.94 |
4.75 |
100.0 |
|
|
|
|
1.18 |
|
|
|
|
21.75 |
1.15 |
1.65 |
3.30 |
0.71 |
2.10 |
|
67 |
|
|
IgG1 |
2a |
1.39e-09 |
6.13e-10 |
2.85e-07 |
|
1.81e-10 |
7.33e-08 |
17500.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
21.7 |
419.0 |
1160.0 |
3404 |
12080 |
|
|
|
1.99e+03 |
3.49e+03 |
4.85e+03 |
0.0 |
|
strong |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.19 |
6.13 |
5.77 |
6.15 |
4.77 |
4.67 |
5.22 |
6.22 |
100.0 |
|
|
|
|
1.33 |
|
|
0.5mg/kg: 152.54|1.5mg/kg: 665.62 |
|
23.10 |
1.22 |
1.30 |
2.60 |
0.56 |
1.65 |
|
68 |
|
|
IgG1 |
2d |
4.3e-11 |
3.61e-11 |
2.89e-09 |
2.82e-07 |
2.05e-09 |
2.36e-09 |
9.83 |
25.8 |
43.8 |
>25000 |
>25000 |
>25000 |
10.3 |
30.1 |
54.8 |
1 |
1 |
>25000 |
>25000 |
|
5.93e+01 |
8.74e+01 |
1.10e+02 |
None |
|
strong |
strong |
strong |
strong |
moderate |
moderate |
strong |
6.39 |
6.33 |
6.03 |
6.46 |
5.73 |
6.14 |
5.91 |
6.59 |
100.0 |
|
|
|
|
1.47 |
|
|
0.5mg/kg: 736.35 |
|
40.55 |
2.14 |
2.33 |
4.65 |
1.39 |
4.07 |
|
69 |
|
|
IgG1 |
1 |
1.36e-09 |
2.2e-10 |
2.67e-08 |
|
7.05e-11 |
8.92e-10 |
6840.0 |
20200.0 |
>25000 |
262.0 |
>25000 |
>25000 |
558.0 |
1730.0 |
2320.0 |
482 |
2470 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
moderate |
moderate |
moderate |
weak |
moderate |
strong |
6.32 |
6.26 |
5.99 |
6.41 |
5.61 |
5.88 |
5.28 |
6.56 |
74.1 |
|
|
|
|
2.52 |
|
|
1.5mg/kg: 501.00 |
|
33.90 |
1.79 |
1.05 |
2.11 |
1.07 |
3.16 |
|
70 |
|
|
|
|
2.62e-09 |
3.79e-09 |
1.3e-07 |
|
6.34e-09 |
|
606.0 |
3820.0 |
9900.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
4929 |
19977 |
>25000 |
>25000 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
weak |
weak |
moderate |
weak |
weak |
weak |
4.21 |
3.9 |
3.89 |
3.75 |
3.48 |
3.93 |
5.0 |
4.72 |
86.9 |
|
|
|
|
1.11 |
|
|
|
|
24.75 |
1.31 |
1.30 |
2.61 |
0.55 |
1.62 |
|
71 |
|
|
|
|
2.51e-09 |
1.27e-09 |
1.29e-07 |
|
5.91e-10 |
|
876.0 |
5810.0 |
18200.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
18221 |
>25000 |
>12500 |
>12500 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
weak |
moderate |
moderate |
weak |
moderate |
moderate |
4.2 |
3.87 |
3.85 |
5.34 |
3.47 |
3.92 |
5.02 |
4.72 |
90.1 |
|
|
|
|
1.26 |
|
|
|
|
23.55 |
1.24 |
1.45 |
2.90 |
0.66 |
1.94 |
|
72 |
|
|
|
|
2.8e-09 |
3.72e-09 |
3.14e-08 |
|
5.65e-09 |
|
137.0 |
536.0 |
1110.0 |
>25000 |
>25000 |
>25000 |
189.0 |
913.0 |
2190.0 |
362 |
898 |
>12500 |
>12500 |
|
5.20e+02 |
1.01e+03 |
1.48e+03 |
|
|
weak |
moderate |
moderate |
weak |
weak |
moderate |
moderate |
4.16 |
3.81 |
3.82 |
3.72 |
3.48 |
3.91 |
4.81 |
4.43 |
98.8 |
|
|
|
|
0.639 |
|
|
|
|
|
|
|
|
|
|
|
73 |
|
|
|
2a |
2.85e-09 |
4.54e-09 |
2.49e-08 |
|
6.99e-09 |
|
302.0 |
1460.0 |
3270.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
364 |
1119 |
>12500 |
>12500 |
|
3.13e+03 |
5.68e+03 |
8.04e+03 |
|
|
weak |
weak |
weak |
weak |
weak |
moderate |
moderate |
4.21 |
4.07 |
3.87 |
3.72 |
3.47 |
3.95 |
4.95 |
4.63 |
100.0 |
|
|
|
|
1.45 |
|
|
|
|
37.85 |
2.00 |
2.06 |
4.11 |
1.43 |
4.21 |
|
74 |
|
|
IgG1 |
3a |
5.52e-10 |
2.73e-10 |
3.42e-08 |
|
1.44e-10 |
5.56e-08 |
78.2 |
2600.0 |
9560.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
78 |
543 |
44 |
220 |
|
1.55e+03 |
3.63e+03 |
5.96e+03 |
0.0 |
|
strong |
strong |
moderate |
weak |
weak |
moderate |
strong |
6.22 |
6.18 |
5.9 |
6.27 |
5.25 |
4.99 |
5.28 |
6.37 |
96.2 |
|
|
|
|
1.7 |
|
|
0.5mg/kg: 511.23|1.5mg/kg: 1286.76 |
|
34.55 |
1.82 |
1.65 |
3.30 |
1.82 |
5.37 |
|
75 |
|
|
IgG1 |
3a |
2.49e-09 |
1.18e-09 |
1.27e-07 |
|
3.92e-10 |
8.85e-08 |
9650.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
379 |
3034 |
689 |
3668 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
moderate |
strong |
moderate |
weak |
weak |
moderate |
moderate |
6.13 |
6.1 |
5.8 |
6.2 |
5.09 |
4.88 |
5.15 |
6.25 |
91.3 |
|
|
|
|
1.68 |
|
|
|
|
35.65 |
1.88 |
2.00 |
4.00 |
1.45 |
4.25 |
|
76 |
|
|
IgG1 |
3a |
3.62e-09 |
1.46e-09 |
1.77e-07 |
|
9.63e-10 |
5.26e-08 |
17600.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
3548 |
11060 |
2214 |
10897 |
|
|
2.50e+04 |
2.50e+04 |
|
|
moderate |
moderate |
moderate |
weak |
weak |
moderate |
weak |
5.99 |
6.03 |
5.71 |
6.08 |
4.5 |
4.42 |
5.13 |
6.11 |
92.6 |
|
|
|
|
2.7 |
|
|
|
|
20.25 |
1.07 |
1.70 |
3.40 |
0.81 |
2.40 |
|
77 |
|
|
IgG1 |
3a |
4.34e-09 |
1.79e-09 |
3.86e-07 |
|
1.07e-09 |
|
24600.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
833.0 |
1010.0 |
1070.0 |
|
|
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
moderate |
weak |
moderate |
strong |
weak |
moderate |
moderate |
5.83 |
5.82 |
5.25 |
5.54 |
3.5 |
3.94 |
4.89 |
5.53 |
78.3 |
|
|
|
|
1.31 |
|
|
|
|
21.05 |
1.11 |
2.21 |
4.42 |
0.87 |
2.56 |
|
78 |
|
|
IgG1 |
5a |
7.18e-10 |
1.87e-10 |
3.93e-07 |
|
1.35e-10 |
|
74.2 |
224.0 |
663.0 |
44.9 |
164.0 |
519.0 |
>25000 |
>25000 |
>25000 |
12 |
44 |
10 |
33 |
|
4.61e+01 |
8.75e+02 |
4.90e+03 |
100.0 |
|
strong |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.23 |
6.21 |
5.91 |
6.32 |
5.5 |
5.57 |
5.57 |
6.44 |
48.7 |
|
|
|
|
2.42 |
del68-69,V70I |
|
0.5mg/kg: 285.14|1.5mg/kg: 1432.71 |
|
38.55 |
2.03 |
1.95 |
3.90 |
1.49 |
4.37 |
|
79 |
|
|
IgG1 |
2a |
8.78e-11 |
6.21e-11 |
7.45e-10 |
2.89e-07 |
3.51e-10 |
1.01e-08 |
53.7 |
140.0 |
235.0 |
315.0 |
>25000 |
>25000 |
39.1 |
80.6 |
129.0 |
0.38 |
3 |
379 |
747 |
|
2.38e+01 |
1.76e+02 |
5.68e+02 |
10.0 |
|
strong |
strong |
strong |
strong |
moderate |
moderate |
moderate |
6.36 |
6.3 |
6.02 |
6.43 |
5.64 |
5.9 |
5.43 |
6.55 |
99.1 |
|
|
|
|
2.93 |
|
|
1.5mg/kg: 8009.08 |
|
31.95 |
1.69 |
1.73 |
3.45 |
2.31 |
6.78 |
|
80 |
|
|
IgG1 |
3a |
2.18e-09 |
1.21e-09 |
1.04e-07 |
|
5.09e-10 |
|
792.0 |
3340.0 |
7600.0 |
371.0 |
3670.0 |
>25000 |
232.0 |
1270.0 |
>25000 |
222 |
1595 |
978 |
3872 |
|
3.58e+03 |
8.52e+03 |
1.42e+04 |
0.0 |
|
strong |
moderate |
moderate |
strong |
weak |
moderate |
moderate |
6.17 |
6.18 |
5.88 |
6.27 |
5.45 |
5.36 |
5.37 |
6.37 |
93.7 |
|
|
|
|
1.98 |
|
|
1.5mg/kg: 2316.58 |
|
31.85 |
1.68 |
1.46 |
2.91 |
1.27 |
3.75 |
|
81 |
|
|
IgG1 |
3a |
1.47e-09 |
8.4e-10 |
9.88e-08 |
|
1.52e-10 |
7.16e-08 |
824.0 |
4140.0 |
9950.0 |
1390.0 |
>25000 |
>25000 |
227.0 |
>25000 |
>25000 |
100 |
627 |
268 |
736 |
|
4.31e+03 |
1.24e+04 |
2.30e+04 |
0.0 |
|
strong |
moderate |
moderate |
moderate |
weak |
moderate |
weak |
6.19 |
6.13 |
5.85 |
6.24 |
5.28 |
5.16 |
5.26 |
6.3 |
86.8 |
|
|
|
|
3.09 |
|
|
0.5mg/kg: 397.89|1.5mg/kg: 1106.86 |
|
24.85 |
1.31 |
2.05 |
4.10 |
0.60 |
1.78 |
|
82 |
|
|
IgG1 |
7b |
1.28e-09 |
1.9e-09 |
3.61e-08 |
|
1.02e-09 |
3.29e-08 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
1950.0 |
3020.0 |
3360.0 |
20205 |
>25000 |
>25000 |
>25000 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
0.0 |
|
strong |
weak |
weak |
weak |
weak |
moderate |
moderate |
6.04 |
6.01 |
5.61 |
5.94 |
4.02 |
4.12 |
5.03 |
5.8 |
33.1 |
|
|
|
|
3.82 |
|
|
1.5mg/kg: 1030.22 |
|
27.35 |
1.44 |
1.12 |
2.24 |
1.23 |
3.60 |
|
83 |
|
|
|
7a |
3.73e-10 |
2.14e-10 |
8.94e-08 |
|
6.75e-11 |
4.35e-08 |
1030.0 |
3200.0 |
6030.0 |
335.0 |
1140.0 |
1700.0 |
380.0 |
>25000 |
>25000 |
99 |
396 |
172 |
503 |
|
2.50e+03 |
2.90e+03 |
3.16e+03 |
10.0 |
|
strong |
weak |
moderate |
moderate |
weak |
moderate |
moderate |
6.3 |
6.22 |
5.94 |
6.28 |
5.04 |
5.1 |
5.29 |
6.26 |
98.0 |
|
|
|
|
3.84 |
|
|
0.5mg/kg: 1033.55|1.5mg/kg: 9035.08 |
|
43.85 |
2.31 |
1.82 |
3.65 |
1.62 |
4.76 |
|
84 |
|
|
|
7a |
4.33e-10 |
2.78e-10 |
9.29e-08 |
|
6.99e-11 |
1.62e-08 |
1570.0 |
4380.0 |
7700.0 |
374.0 |
1440.0 |
2000.0 |
569.0 |
2190.0 |
5470.0 |
49 |
175 |
225 |
573 |
|
1.27e+03 |
2.07e+03 |
2.75e+03 |
0.0 |
|
strong |
weak |
moderate |
weak |
weak |
moderate |
moderate |
6.31 |
6.23 |
5.95 |
6.32 |
5.04 |
5.12 |
5.31 |
6.31 |
96.2 |
|
|
|
|
1.36 |
E654A|R408G |
|
1.5mg/kg: 9120.49 |
|
25.15 |
1.33 |
0.93 |
1.85 |
2.26 |
6.65 |
|
85 |
|
|
IgG1 |
3a |
2.59e-09 |
8.04e-10 |
1.51e-07 |
|
2.71e-10 |
1.25e-07 |
|
|
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
284 |
786 |
429 |
1762 |
|
9.62e+03 |
3.59e+04 |
7.77e+04 |
|
|
strong |
moderate |
moderate |
weak |
weak |
moderate |
moderate |
6.07 |
6.09 |
5.73 |
6.12 |
4.79 |
4.63 |
5.28 |
6.06 |
93.2 |
|
|
|
|
3.81 |
|
|
|
|
44.55 |
2.35 |
1.95 |
3.90 |
1.45 |
4.26 |
|
86 |
|
|
IgG1 |
|
2.16e-09 |
4.41e-10 |
1.03e-07 |
|
3.15e-10 |
1.03e-07 |
6150.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
691 |
4356 |
|
1.68e+04 |
4.58e+04 |
8.24e+04 |
|
|
moderate |
moderate |
moderate |
weak |
weak |
moderate |
moderate |
6.21 |
6.18 |
5.92 |
6.3 |
5.38 |
5.42 |
5.32 |
6.39 |
96.8 |
|
|
|
|
2.05 |
|
|
|
|
36.45 |
1.92 |
2.13 |
4.26 |
1.18 |
3.46 |
|
87 |
|
|
IgG4 |
|
|
|
|
|
|
|
|
|
|
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
|
|
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
|
|
weak |
moderate |
weak |
weak |
weak |
moderate |
weak |
4.0 |
3.79 |
3.62 |
3.71 |
3.46 |
3.9 |
4.91 |
4.65 |
8.2 |
|
|
|
|
1.22 |
|
|
|
|
30.20 |
1.59 |
1.80 |
3.60 |
1.15 |
3.38 |
|
88 |
|
|
IgG1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
89 |
|
|
IgG1 |
1 |
1.22e-09 |
5.64e-10 |
6.73e-08 |
|
1.49e-10 |
2.81e-09 |
536.0 |
2130.0 |
4470.0 |
412.0 |
1450.0 |
2380.0 |
82.5 |
406.0 |
>25000 |
417 |
1117 |
|
|
|
4.46e+03 |
2.17e+04 |
5.46e+04 |
0.0 |
|
weak |
moderate |
weak |
weak |
weak |
moderate |
moderate |
6.07 |
6.24 |
5.73 |
5.62 |
5.42 |
3.93 |
4.13 |
5.21 |
60.9 |
|
|
|
|
1.44 |
|
|
1.5mg/kg: 114.40 |
|
31.75 |
1.68 |
1.60 |
3.20 |
1.72 |
5.06 |
|
90 |
|
|
IgG1 |
2c |
2.93e-10 |
1.27e-10 |
1.1e-07 |
|
1.86e-09 |
|
380.0 |
1190.0 |
2110.0 |
1040.0 |
1520.0 |
1670.0 |
>25000 |
>25000 |
>25000 |
218 |
1357 |
|
|
|
1.89e+03 |
4.31e+03 |
6.98e+03 |
|
|
moderate |
weak |
moderate |
strong |
weak |
moderate |
moderate |
6.33 |
6.26 |
5.97 |
6.38 |
5.53 |
5.74 |
5.59 |
6.49 |
100.0 |
|
|
|
|
1.57 |
|
|
|
|
26.25 |
1.39 |
1.67 |
3.34 |
0.80 |
2.35 |
|
91 |
|
|
IgG1 |
4c |
2.43e-10 |
5.69e-10 |
4.69e-09 |
4.46e-06 |
6.46e-10 |
3.48e-09 |
327.0 |
1660.0 |
4940.0 |
814.0 |
1220.0 |
1350.0 |
>25000 |
>25000 |
>25000 |
66 |
680 |
4846 |
10146 |
|
2.50e+04 |
2.50e+04 |
2.50e+04 |
None |
|
strong |
weak |
strong |
strong |
moderate |
moderate |
moderate |
6.26 |
6.23 |
5.91 |
6.34 |
5.48 |
5.57 |
5.53 |
6.39 |
21.7 |
|
|
|
|
3.92 |
|
|
0.5mg/kg: 1375.38 |
|
49.40 |
2.61 |
1.06 |
2.13 |
1.41 |
4.13 |
|
92 |
|
|
IgG1 |
2c |
1.04e-09 |
5.73e-10 |
1.96e-07 |
|
|
|
208.0 |
521.0 |
918.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
144 |
368 |
|
|
|
5.92e+02 |
1.03e+03 |
1.43e+03 |
|
|
strong |
moderate |
moderate |
moderate |
weak |
moderate |
moderate |
6.12 |
6.08 |
5.8 |
6.18 |
3.8 |
5.13 |
5.23 |
6.17 |
91.2 |
|
|
|
|
1.49 |
|
|
|
|
51.95 |
2.74 |
1.33 |
2.66 |
1.75 |
5.15 |
|
93 |
|
|
IgG2 |
1 |
1.02e-10 |
2.7e-11 |
4.31e-10 |
6.52e-07 |
2.02e-11 |
5.53e-10 |
69.3 |
225.0 |
407.0 |
26.9 |
89.8 |
199.0 |
26.2 |
70.1 |
138.0 |
>25000 |
>25000 |
|
|
|
7.05e+01 |
9.92e+01 |
1.21e+02 |
0.0 |
|
moderate |
weak |
strong |
strong |
weak |
moderate |
moderate |
6.37 |
6.32 |
5.99 |
3.8 |
5.77 |
4.36 |
4.73 |
4.56 |
95.4 |
|
|
|
|
1.43 |
R685S |
|
0.5mg/kg: 66.10|1.5mg/kg: 295.85 |
|
24.60 |
1.30 |
1.50 |
3.00 |
0.62 |
1.82 |
|
94 |
|
|
IgG1 |
4a |
1.04e-10 |
1.1e-10 |
5.62e-09 |
|
4.35e-11 |
2.77e-11 |
35.2 |
96.8 |
167.0 |
16.2 |
42.7 |
73.1 |
>25000 |
>25000 |
>25000 |
4 |
8 |
2 |
6 |
|
8.87e+01 |
1.38e+02 |
1.79e+02 |
90.0 |
|
moderate |
moderate |
weak |
weak |
weak |
weak |
weak |
6.18 |
6.19 |
5.84 |
6.08 |
4.29 |
4.6 |
5.42 |
6.02 |
98.0 |
|
|
|
|
1.64 |
|
|
0.5mg/kg: 2121.07|1.5mg/kg: 7219.93 |
|
34.20 |
1.80 |
1.60 |
3.20 |
1.05 |
3.10 |
|
95 |
|
|
IgG1 |
4a |
8.41e-11 |
4.88e-11 |
2.75e-08 |
|
2.51e-10 |
3.28e-10 |
21.2 |
63.8 |
122.0 |
>25000 |
>25000 |
>25000 |
24.2 |
6.69 |
3.65 |
0.34 |
1 |
798 |
14 |
|
1.24e+02 |
3.45e+02 |
6.26e+02 |
None |
|
strong |
moderate |
weak |
weak |
weak |
moderate |
moderate |
6.18 |
6.12 |
5.69 |
6.07 |
4.3 |
4.49 |
5.02 |
6.15 |
98.8 |
|
|
|
|
1.93 |
|
|
0.5mg/kg: 2508.19 |
|
24.90 |
1.31 |
1.35 |
2.70 |
0.52 |
1.53 |
|
96 |
|
|
IgG1 |
5a |
7.65e-11 |
5.66e-11 |
9.22e-08 |
|
4.7e-11 |
|
21.3 |
59.4 |
112.0 |
15.5 |
78.9 |
191.0 |
27.7 |
114.0 |
267.0 |
<0.32 |
6 |
0.51 |
11 |
|
5.77e+01 |
1.76e+02 |
3.38e+02 |
None |
|
moderate |
weak |
weak |
moderate |
weak |
moderate |
strong |
6.02 |
6.18 |
5.41 |
6.01 |
4.99 |
4.16 |
5.09 |
6.24 |
44.8 |
|
|
|
|
1.26 |
G339C |
|
0.5mg/kg: 1912.34 |
|
|
|
|
|
|
|
|
97 |
|
|
IgG1 |
1 |
1.31e-11 |
6.31e-12 |
4.96e-09 |
3.41e-06 |
1.31e-11 |
6.2e-09 |
6.35 |
19.1 |
33.5 |
6.8 |
32.1 |
75.1 |
3.02 |
9.83 |
17.7 |
<0.32 |
1 |
<0.32 |
6 |
|
8.25e+01 |
1.41e+02 |
1.93e+02 |
30.0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
100.0 |
|
|
|
|
1.4 |
|
|
0.5mg/kg: 5702.68 |
|
|
|
|
|
|
|
|
98 |
|
|
IgG1 |
1 |
7.35e-11 |
6.51e-11 |
3.82e-09 |
|
4.23e-11 |
2.66e-09 |
130.0 |
416.0 |
764.0 |
26.9 |
131.0 |
378.0 |
50.1 |
169.0 |
330.0 |
18 |
66 |
2 |
14 |
|
2.89e+02 |
4.28e+02 |
5.38e+02 |
10.0 |
|
strong |
moderate |
weak |
strong |
weak |
strong |
moderate |
6.07 |
6.06 |
5.37 |
6.06 |
4.32 |
4.17 |
5.07 |
6.11 |
98.5 |
|
|
|
|
1.67 |
|
|
0.5mg/kg: 1495.80|1.5mg/kg: 4438.01 |
|
|
|
|
|
|
|
|
99 |
|
|
IgG1 |
2c |
4.03e-11 |
2.13e-11 |
2.47e-09 |
1.42e-06 |
|
1.37e-08 |
13.8 |
35.8 |
60.1 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
<0.32 |
<0.32 |
1605 |
3436 |
|
8.36e+01 |
1.51e+02 |
2.14e+02 |
10.0 |
|
strong |
moderate |
moderate |
moderate |
weak |
moderate |
moderate |
6.28 |
6.16 |
5.95 |
6.13 |
4.96 |
5.37 |
5.33 |
6.22 |
100.0 |
|
|
|
|
1.55 |
|
|
0.5mg/kg: 2091.21|1.5mg/kg: 7010.57 |
|
|
|
|
|
|
|
|
100 |
|
|
IgG1 |
2b |
1.45e-11 |
8.37e-12 |
3.3e-09 |
1.61e-06 |
1.44e-11 |
3.66e-09 |
7.45 |
18.1 |
29.7 |
14.0 |
65.6 |
165.0 |
2.87 |
10.4 |
21.8 |
1 |
3 |
9 |
29 |
|
1.82e+01 |
2.93e+01 |
3.87e+01 |
80.0 |
|
strong |
strong |
moderate |
moderate |
weak |
moderate |
strong |
6.28 |
6.13 |
6.05 |
6.19 |
5.07 |
5.56 |
5.21 |
6.27 |
100.0 |
|
|
|
|
2.19 |
|
|
0.5mg/kg: 3457.40|1.5mg/kg: 12740.40 |
|
|
|
|
|
|
|
|
101 |
|
|
IgG1 |
4b |
2.99e-11 |
2.26e-11 |
3.94e-09 |
|
2.7e-11 |
6.43e-11 |
11.3 |
27.7 |
45.2 |
6.3 |
20.1 |
36.8 |
8.52 |
45.0 |
96.2 |
6 |
21 |
9 |
22 |
|
9.78e+01 |
2.27e+02 |
3.72e+02 |
90.0 |
|
strong |
moderate |
weak |
moderate |
weak |
strong |
strong |
6.26 |
6.19 |
6.02 |
6.11 |
5.09 |
5.68 |
5.58 |
6.27 |
100.0 |
|
|
|
|
2.7 |
S494L |
|
0.5mg/kg: 2611.60|1.5mg/kg: 10051.28 |
|
|
|
|
|
|
|
|
102 |
|
|
|
2b |
1.43e-10 |
6.77e-11 |
1.45e-09 |
4.98e-07 |
3.59e-11 |
|
5.78 |
15.8 |
27.0 |
4.47 |
10.6 |
17.1 |
2.81 |
7.3 |
10.2 |
<0.32 |
<0.32 |
<0.32 |
<0.32 |
|
2.16e+00 |
1.06e+01 |
2.67e+01 |
0.0 |
|
weak |
weak |
weak |
weak |
weak |
weak |
weak |
3.84 |
3.91 |
3.64 |
3.33 |
4.22 |
3.8 |
4.63 |
4.25 |
84.3 |
|
|
|
|
1.3 |
|
|
0.5mg/kg: 50.30|1.5mg/kg: 50.30 |
|
19.05 |
1.07 |
1.21 |
1.13 |
0.49 |
1.88 |
|
103 |
|
|
|
2b |
8.34e-11 |
1.22e-10 |
1.62e-09 |
4.77e-07 |
5.37e-11 |
3.25e-10 |
8.82 |
24.4 |
42.6 |
>25000 |
>25000 |
20.0 |
>25000 |
13.6 |
26.1 |
<0.32 |
<0.32 |
<0.32 |
<0.32 |
|
2.17e+01 |
4.28e+01 |
6.38e+01 |
|
|
weak |
weak |
weak |
weak |
weak |
weak |
weak |
3.83 |
3.71 |
3.62 |
3.36 |
4.17 |
3.76 |
4.69 |
4.27 |
84.9 |
|
|
|
|
1.21 |
|
|
|
|
24.45 |
1.37 |
1.12 |
1.05 |
0.48 |
1.85 |
|
104 |
|
|
|
2b |
9.36e-11 |
8.39e-11 |
1.37e-09 |
6.74e-11 |
5.15e-10 |
|
16.8 |
26.2 |
33.8 |
60.2 |
204.0 |
444.0 |
264.0 |
631.0 |
1060.0 |
<0.32 |
<0.32 |
3 |
7 |
|
4.42e+00 |
6.57e+00 |
8.28e+00 |
|
|
weak |
weak |
weak |
weak |
moderate |
weak |
weak |
3.8 |
3.74 |
3.63 |
3.33 |
4.22 |
3.78 |
4.78 |
4.24 |
86.1 |
|
|
|
|
1.22 |
|
|
|
|
23.20 |
1.30 |
1.56 |
1.46 |
0.36 |
1.38 |
|
105 |
|
|
IgG1 |
2d |
2.15e-11 |
1.26e-11 |
1.62e-08 |
|
5.44e-10 |
|
335.0 |
876.0 |
1520.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
23 |
68 |
>25000 |
>25000 |
|
1.86e+02 |
1.95e+02 |
2.00e+02 |
|
|
moderate |
moderate |
moderate |
moderate |
weak |
moderate |
weak |
6.27 |
6.19 |
6.01 |
6.14 |
4.36 |
5.63 |
5.38 |
6.25 |
100.0 |
|
|
|
|
1.45 |
Q493H,R685S |
|
|
|
16.35 |
0.92 |
1.37 |
1.28 |
0.24 |
0.94 |
|
106 |
|
|
IgG1 |
2d |
1.3e-11 |
6.62e-12 |
9.24e-10 |
2.79e-07 |
3.66e-10 |
|
6.85 |
18.4 |
31.3 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
<0.32 |
2 |
864 |
2686 |
|
1.34e+00 |
2.12e+00 |
2.78e+00 |
None |
|
moderate |
strong |
moderate |
weak |
weak |
weak |
weak |
6.3 |
6.14 |
5.99 |
6.19 |
4.82 |
5.55 |
5.42 |
6.25 |
100.0 |
|
|
|
|
1.66 |
S494L |
|
0.5mg/kg: 4633.30 |
|
|
|
|
|
|
|
|
107 |
|
|
IgG1 |
2d |
2.23e-11 |
1e-11 |
9.39e-10 |
2.26e-07 |
3.61e-10 |
1.56e-07 |
8.2 |
28.9 |
54.0 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
>25000 |
<0.32 |
1 |
302 |
889 |
|
2.02e+01 |
2.78e+01 |
3.36e+01 |
None |
|
strong |
strong |
moderate |
moderate |
weak |
moderate |
moderate |
6.31 |
6.22 |
6.07 |
6.18 |
5.19 |
5.62 |