CoVIC ID Antibody information Antibody features Affinity, KD (M) - Duke Pseudovirus neutralization (ng/mL) Pseudovirus neutralization - Beta (ng/mL) Pseudovirus neutralization - Delta (ng/mL) Authentic virus neutralization (ng/mL) - UNC Authentic virus neutralization (ng/mL) - UTMB In vivo protection survival (%) Fc Activity - Ragon Complex formation inhibition (%) Antibody dependent enhancement UTMB - ADMP sequence / structural features Nexelis - PK Details
Unbinded ID Organization Isotype Epitope Community (RBD) D614 D614G RBD NTD B.1.351 Omicron IC50- Pseudovirus neutralization (ng/mL) IC80- Pseudovirus neutralization (ng/mL) IC90- Pseudovirus neutralization (ng/mL) IC50- Pseudovirus neutralization, Beta (ng/mL) IC80- Pseudovirus neutralization, Beta (ng/mL) IC90- Pseudovirus neutralization, Beta(ng/mL) IC50- Pseudovirus neutralization, Delta (ng/mL) IC80- Pseudovirus neutralization, Delta (ng/mL) IC90- Pseudovirus neutralization, Delta (ng/mL) IC50 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC80 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC90 (WA-1)- Authentic virus neutralization, UNC (ng/mL) IC50 (B.1.351)- Authentic virus neutralization, UNC (ng/mL) IC80 (B.1.351)- Authentic virus neutralization, UNC (ng/mL) IC50- UTMB - Authentic virus neutralization, UTMB (ng/mL) IC80- UTMB - Authentic virus neutralization, UTMB (ng/mL) IC90- UTMB - Authentic virus neutralization, UTMB (ng/mL) K18 mice hamsters ADCP mADCP ADNP mADNP ADCD (MFI C3) ADNKA % CD107a+ ADNKA % MIP-1b+ FcgR2aR (MFI) FcgR3aV (MFI) FcgR2b (MFI) FcgR3b (MFI) FcRn (MFI) mFcR2 (MFI) mFcR3 (MFI) mFcR4 (MFI) Spike: ACE2 Score (for level of ADE at 10 ug/mL) IC50- Antibody dependent enhancement IC80- Antibody dependent enhancement IC90- Antibody dependent enhancement Fold increase over virus control Escape Structure GMC for Pre-Spike IgG GMC for RBD IgG
CC12.3 None 5035 16232 57.666666666666664 1.4
Untreated Infected Control None None
Mock Infected Control None None
mAb-251 None 0.0
CR3022 None moderate weak weak moderate weak strong strong 5.99 6.11 4.78 5.73 3.94 5.12 5.3 6.16
KZ52 None weak moderate weak strong weak weak weak 4.06 3.84 4.38 3.7 3.78 3.59 4.4 4.29
negative plasma None weak moderate weak weak strong weak weak 4.01 3.79 4.33 3.7 3.76 3.58 4.33 4.2
CC12.14 None 1299 4989 2.1
1 IgG1 1 1.63e-09 1.75e-10 1.46e-06 4.19e-08 1830.0 6370.0 14100.0 2430.0 2510.0 2530.0 202.0 >25000 >25000 245 662 1.24e+03 1.65e+03 1.95e+03 weak moderate weak strong moderate weak moderate 6.09 6.05 5.48 4.83 3.5 3.93 4.87 5.66 69.6 1.2
2 IgG1 2b 1.24e-10 5.16e-11 1.23e-07 1.33e-11 1470.0 4010.0 7910.0 20.6 89.3 209.0 >25000 >25000 >25000 19 60 3.03e+02 4.69e+02 6.05e+02 10.0 strong strong strong strong moderate moderate moderate 6.34 6.28 6.01 6.42 5.65 5.96 5.89 6.63 100.0 2.0 Y489H 0.5mg/kg: 2065.60|1.5mg/kg: 7474.30
3 IgG1 2c 1.47e-09 8.3e-10 8.93e-07 2320.0 8360.0 16000.0 705.0 2850.0 4420.0 >25000 >25000 >25000 846 2766 3.20e+03 6.50e+03 9.84e+03 0.0 weak weak weak strong weak moderate moderate 5.87 5.99 5.0 4.39 3.63 3.94 4.68 5.03 90.3 1.12 1.5mg/kg: 1527.28
4 IgG1 2d 2.43e-10 8.05e-11 1.11e-07 1.84e-08 709.0 2480.0 5020.0 1530.0 1560.0 1570.0 759.0 5560.0 >25000 179 450 1.49e+03 2.73e+03 3.88e+03 moderate weak weak strong weak moderate weak 6.21 6.23 5.66 5.54 4.92 3.95 4.76 5.47 100.0 1.07
5 IgG1 2c 1.08e-09 8.64e-10 3.98e-07 853.0 2600.0 5260.0 29.8 186.0 406.0 158.0 415.0 679.0 433 754 1.57e+04 1.84e+04 2.02e+04 0.0 weak weak weak moderate weak moderate moderate 6.05 6.08 5.36 5.14 4.56 3.94 4.77 5.14 98.2 1.23 1.5mg/kg: 1243.76
6 169-178 Myrio Tx IgG1 2a 5.53e-10 3.53e-10 8.71e-08 5.98e-10 >25000 >25000 >25000 >25000 >25000 >25000 21.4 102.0 249.0 11861 22679 2.52e+02 4.86e+02 7.14e+02 moderate moderate weak weak moderate moderate weak 6.05 5.94 5.65 5.87 4.09 4.59 5.11 5.91 99.0 1.28
7 167-230 Myrio Tx IgG1 6b 1.21e-10 3.66e-11 1.72e-08 4.5e-06 4.92e-09 53.8 146.0 261.0 >25000 >25000 >25000 >25000 >25000 >25000 18 33 2.50e+04 2.50e+04 2.50e+04 10.0 moderate moderate moderate moderate weak moderate weak 6.09 6.0 5.71 5.98 4.58 4.57 4.92 6.15 100.0 2.51 0.5mg/kg: 1789.63|1.5mg/kg: 7481.71
8 171-155 Myrio Tx IgG1 6b 6.75e-10 4.51e-10 2.36e-08 1.34e-10 12800.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2191 6355 1.02e+04 1.13e+04 1.21e+04 moderate weak moderate weak weak moderate weak 6.34 6.28 6.01 6.38 5.35 5.49 5.22 6.41 98.0 2.85
9 CT-01 Celltrion IgG1 2c 1.65e-11 7.06e-12 2.33e-10 9.29e-08 3.63e-11 2.13e-08 12.6 24.0 34.1 >25000 >25000 >25000 1140.0 1170.0 1170.0 <0.32 0.54 3035 4766 4.83e+00 8.61e+00 1.21e+01 None weak weak weak moderate weak moderate weak 3.75 3.75 3.67 3.72 3.45 3.87 4.18 4.64 100.0 1.96 0.5mg/kg: 2099.34
10 CT-02 Celltrion IgG1 2c 1.84e-11 8.3e-12 2.04e-10 8.55e-08 3.92e-11 3.14e-08 10.1 21.2 32.7 464.0 2300.0 7470.0 51.2 325.0 907.0 <0.32 1 5862 15389 1.18e+01 2.19e+01 3.15e+01 None weak weak weak weak weak weak weak 3.78 3.74 3.7 3.71 3.46 3.86 4.26 4.24 100.0 1.29 0.5mg/kg: 3133.56
11 CT-03 Celltrion IgG1 2c 2.35e-11 9.87e-12 2.11e-10 4.67e-08 2.81e-11 4.85e-09 6.09 16.2 28.0 >25000 >25000 >25000 159.0 656.0 1520.0 <0.32 0.93 137 196 1.78e+01 2.62e+01 3.28e+01 90.0 weak moderate weak moderate weak moderate weak 3.86 3.77 3.74 3.69 3.45 3.89 4.09 4.16 99.4 0.893 0.5mg/kg: 2060.71|1.5mg/kg: 8050.89
12 CT-04 Celltrion IgG1 2c 1.11e-11 5.07e-12 1.64e-10 7.55e-08 4.24e-11 3.66e-08 7.48 18.6 30.6 990.0 1190.0 1250.0 352.0 1050.0 1450.0 <0.32 <0.32 2526 4536 8.62e+00 1.43e+01 1.93e+01 None weak strong weak strong weak moderate weak 3.67 3.75 3.62 3.71 3.45 3.88 4.14 4.2 100.0 2.42 0.5mg/kg: 2732.99
13 CT-05 Celltrion IgG1 2c 8.95e-12 4.71e-12 1.16e-10 5.11e-08 2.42e-11 6.07 15.4 25.3 71.7 235.0 459.0 19.4 54.8 97.5 <0.32 0.85 159 627 4.75e+00 7.05e+00 8.88e+00 70.0 weak weak weak strong weak moderate moderate 4.04 4.43 3.8 3.72 3.48 3.91 4.82 4.76 100.0 3.3 0.5mg/kg: 4115.36|1.5mg/kg: 10520.90
14 R15-F7 Sanyou Biopharmaceuticals IgG1 2d 4.43e-11 1.1e-11 1.94e-09 1.14e-06 5.3e-11 5.45e-08 9.75 24.7 42.9 >25000 >25000 >25000 373.0 1490.0 7440.0 <0.32 <0.32 >12500 >12500 6.70e-01 1.42e+00 2.21e+00 strong strong strong strong moderate moderate strong 6.37 6.32 6.02 6.46 5.71 5.99 5.74 6.6 100.0 3.49
15 P4-F6 Sanyou Biopharmaceuticals IgG1 2d 9.47e-11 4.56e-11 1.19e-08 1.19e-07 1.22e-09 2.88e-09 32.0 107.0 223.0 >25000 >25000 >25000 1610.0 3140.0 3780.0 1 10 >12500 >12500 3.12e+01 4.93e+01 6.44e+01 strong strong strong strong strong moderate moderate 6.38 6.33 6.04 6.45 5.74 6.08 5.86 6.63 100.0 3.63
16 aS-RBD Sanyou Biopharmaceuticals IgG1 2a 1.57e-10 5.04e-11 5.31e-09 1.03e-06 7.34e-10 9.66e-09 44.5 180.0 388.0 995.0 >25000 >25000 215.0 888.0 1380.0 10518 >25000 1.61e+04 8.58e+04 2.28e+05 moderate weak weak strong weak moderate moderate 6.15 6.15 5.36 3.9 5.09 3.94 4.91 5.04 100.0 1.54
17 a@-RBD Single chain Sanyou Biopharmaceuticals IgG1 4b 5.04e-10 4.01e-10 3.46e-08 1.81e-10 2.82e-09 1030.0 3020.0 5630.0 >25000 >25000 >25000 >25000 >25000 >25000 8726 24853 2.50e+04 2.50e+04 2.50e+04 strong moderate moderate moderate moderate moderate moderate 6.33 6.28 5.99 6.4 5.49 5.67 5.66 6.51 67.0 5.79
18 IgG
19 IgG 1.08e-09 1.18e-09 2.64e-08 39.7 140.0 262.0 664.0 >25000 >25000 >25000 >25000 >25000 433 1516 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak moderate weak 4.07 3.8 3.83 3.73 3.45 3.93 4.75 4.54 23.7 1.42
20 TB181-8 Twist Bioscience IgG1 7.59e-10 8.13e-10 8.15e-08 1.36e-09 2.32e-09 72.3 587.0 >25000 639.0 1160.0 1350.0 >25000 >25000 >25000 236 4924 2.59e+03 9.47e+03 2.02e+04 10.0 strong moderate moderate strong strong moderate strong 6.09 6.0 5.77 6.02 4.23 4.57 5.23 6.07 9.0 3.64 0.5mg/kg: 50.30|1.5mg/kg: 58.71
21 TB182-3 Twist Bioscience IgG1 7c 5.02e-10 1.4e-09 2.08e-10 5.25e-10 9.26e-09 12500.0 >25000 >25000 162.0 >25000 >25000 >25000 >25000 >25000 8582 20807 1.99e+04 3.48e+04 4.82e+04 0.0 strong moderate moderate moderate moderate moderate weak 6.29 6.22 5.95 6.3 5.2 5.14 5.34 6.28 11.6 2.69 0.5mg/kg: 134.98|1.5mg/kg: 643.01
22 TB182-4 Twist Bioscience IgG1 6a 1.08e-09 3e-09 1.04e-07 3.68e-10 1.84e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak moderate weak weak moderate weak 6.24 6.2 5.89 6.22 5.0 4.63 5.2 6.11 51.1 2.95 1.5mg/kg: 1601.37
23 TB182-7 Twist Bioscience IgG1 5b 3.72e-10 5.86e-10 7.13e-08 2e-10 4.25e-09 14200.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong moderate moderate weak moderate moderate weak 6.27 6.22 5.93 6.27 4.82 5.04 5.09 6.27 36.3 5.49 1.5mg/kg: 158.53
24 AB-3828 Generate Biomedicines IgG1 7b 1.21e-09 2.3e-09 1.46e-08 7.49e-10 2.55e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 14175 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 moderate strong weak weak weak strong moderate 6.22 6.18 5.86 6.23 5.08 4.78 5.17 6.21 48.7 3.48 1.5mg/kg: 3119.58
25 AB-3831 Generate Biomedicines IgG1 7b 1.07e-09 1.9e-09 8.49e-08 6.96e-09 8.2e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate strong moderate weak moderate moderate 5.77 5.93 5.07 5.59 3.78 4.02 4.91 5.71 31.2 2.47
26 AB-3836 Generate Biomedicines IgG1 7b 6.57e-10 1.18e-09 3.88e-08 5.36e-09 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak moderate strong weak moderate moderate 6.22 6.14 5.81 6.16 4.75 4.54 5.25 6.14 31.8 5.8 1.5mg/kg: 630.67
27 AB-4149 Generate Biomedicines IgG1 3a 3.59e-09 1.42e-09 1.48e-07 2.62e-10 8.91e-08 8250.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 260 2457 1173 4632 2.07e+04 3.24e+04 4.22e+04 strong moderate moderate strong weak moderate moderate 6.19 6.13 5.87 6.24 5.23 5.04 5.3 6.34 88.6 6.13
28 IgG1 6b 3.3e-10 5.22e-10 1.23e-08 1.26e-10 2.32e-08 512.0 1960.0 3960.0 755.0 1400.0 1760.0 308.0 >25000 >25000 190 815 398 897 3.19e+03 4.68e+03 5.85e+03 0.0 strong moderate moderate strong weak moderate moderate 6.36 6.3 6.02 6.42 5.63 5.9 5.61 6.55 100.0 6.13 0.5mg/kg: 1908.96|1.5mg/kg: 3954.73
29 IgG1 4.33e-10 3.5e-10 3.99e-07 1020.0 1520.0 1750.0 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate weak weak strong weak moderate weak 6.24 6.18 5.89 6.2 4.64 4.74 5.15 6.16 5.0
30 IgG1 2d 3.21e-11 5.94e-12 4.1e-09 2.73e-06 8.87 26.8 50.7 518.0 1650.0 >25000 47.1 113.0 200.0 2 6 >25000 >25000 2.75e+01 5.23e+01 7.61e+01 100.0 strong strong strong moderate moderate moderate moderate 6.36 6.3 6.02 6.45 5.72 6.06 5.53 6.59 100.0 7.37 E484A 0.5mg/kg: 2456.41|1.5mg/kg: 8195.59
31 IgG1 4b 1.42e-10 8.08e-11 7.02e-08 3.96e-10 11400.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 949 2233 1.21e+04 4.33e+04 9.12e+04 10.0 strong weak moderate moderate moderate moderate moderate 6.3 6.26 5.97 6.4 5.68 6.03 5.67 6.6 99.0 2.57 1.5mg/kg: 2850.55
32 IgG1 2d 5.76e-11 1.85e-11 1.76e-09 1.96e-06 2.04e-10 8.66 32.3 66.4 >25000 >25000 >25000 1.08 1.06 1.06 2 8 735 2676 6.11e+01 1.44e+02 2.37e+02 60.0 strong strong strong moderate moderate moderate weak 6.39 6.32 6.05 6.46 5.72 6.08 5.68 6.61 100.0 2.65 G496V|S494L 0.5mg/kg: 3150.21|1.5mg/kg: 6774.03
33 IgG1 3.32e-08 1.63e-08 4.8e-06 8.18e-08 >25000 >25000 >25000 >25000 >25000 >25000 5650.0 7400.0 7930.0 18 44 259 637 4.57e+03 6.06e+03 7.14e+03 10.0 strong weak weak weak weak moderate moderate 4.35 4.01 3.81 3.77 3.48 3.94 4.91 5.23 7.6 3.29
34 IgG1 2.37e-09 1.74e-09 3.92e-09 5.29e-08 162.0 453.0 1050.0 1.13 1.12 1.12 >25000 >25000 >25000 201 19356 1.02e+04 2.14e+04 3.30e+04 0.0 moderate moderate weak weak weak moderate strong 6.0 5.97 5.52 5.7 4.31 4.12 5.01 5.71 6.4 2.3 1.5mg/kg: 50.30
35 IgG1 7c 1.68e-09 1.05e-09 2.81e-09 4.34e-10 2.3e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong strong moderate weak weak moderate weak 6.21 6.2 5.9 6.25 5.33 5.21 5.31 6.22 7.1 3.24 1.5mg/kg: 1842.61
36 IgG1 4.36e-09 4.96e-09 9.51e-07 86.2 6600.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 4 14 >25000 >25000 3.07e+01 1.18e+02 2.59e+02 60.0 moderate moderate weak weak weak moderate weak 6.18 6.11 5.87 6.18 5.04 5.07 5.06 6.21 3.1 del68-70 0.5mg/kg: 63.45
37 IgG1 1.9e-08 3.96e-08 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak weak weak moderate weak 5.19 5.28 4.44 4.15 3.53 3.92 4.86 5.2 3.9 0.459
38 GSV0-P14-F8 Sanyou Biopharmaceuticals IgG 6b 1.09e-09 4.54e-10 7.05e-09 1.4e-10 297.0 1310.0 2900.0 863.0 2170.0 2740.0 376.0 1820.0 2920.0 16 78 41 123 3.45e+02 7.16e+02 1.10e+03 None moderate moderate moderate strong moderate moderate strong 6.35 6.3 6.01 6.42 5.52 5.76 5.48 6.45 99.3 1.05 0.5mg/kg: 176.64
39 GSV0-P15-F7 Sanyou Biopharmaceuticals IgG 2d 3.12e-11 1.06e-11 1.78e-09 1.66e-06 3.33e-08 4.13e-08 7.11 20.1 35.8 >25000 >25000 >25000 124.0 333.0 750.0 <0.32 <0.32 12500 12500 1.66e+01 2.68e+01 3.56e+01 None strong strong strong strong moderate moderate moderate 6.36 6.32 6.03 6.47 5.71 6.01 5.7 6.61 100.0 1.47 L452P 0.5mg/kg: 3296.86
40 GSV0-P9-F7 Sanyou Biopharmaceuticals IgG 2d 7.15e-11 3.82e-11 1.68e-08 6.92e-09 4.03e-08 248.0 825.0 1590.0 >25000 >25000 >25000 289.0 1540.0 3400.0 76 216 >25000 >25000 4.76e+02 1.46e+03 2.80e+03 None strong moderate strong strong weak moderate moderate 6.37 6.31 6.03 6.45 5.71 6.06 5.82 6.63 100.0 0.868 F490C|F490L|F490V 0.5mg/kg: 1926.61
41 CV1 Fred Hutchinson Cancer Research Center IgG1 2.33e-10 2.49e-10 2.75e-08 1.06e-10 7.77e-10 6450.0 23200.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 5997 >25000 2.50e+04 2.50e+04 2.50e+04 100.0 strong weak moderate moderate weak moderate weak 6.3 6.25 5.95 6.35 5.51 5.6 4.6 6.36 1.02 1.5mg/kg: 15897.03
42 CV30 Fred Hutchinson Cancer Research Center IgG1 2a 4.84e-10 1.59e-10 1.1e-08 4.47e-10 57.6 185.0 348.0 1000.0 21700.0 >25000 13.8 53.8 124.0 14 44 2246 6637 7.81e+02 1.81e+03 2.95e+03 0.0 strong moderate strong moderate moderate moderate moderate 6.37 6.3 6.02 6.45 5.61 5.87 5.44 6.56 98.8 0.626 0.5mg/kg: 3894.89
43 IgG4 2c 1.94e-10 9.59e-11 2.27e-08 1.48e-08 34.1 109.0 210.0 >25000 >25000 >25000 3.2 17.5 47.5 13 31 1672 3234 1.22e+03 2.06e+03 2.81e+03 10.0 strong weak moderate weak weak moderate moderate 6.38 6.11 6.01 3.8 5.72 4.02 4.25 4.98 100.0 0.718 0.5mg/kg: 206.34|1.5mg/kg: 778.93
44 IgG1 2c 1.42e-10 1.98e-10 4.74e-08 53.4 163.0 302.0 >25000 >25000 >25000 102.0 265.0 432.0 5 19 >25000 >25000 4.26e+02 1.01e+03 1.66e+03 30.0 strong moderate moderate moderate weak moderate weak 6.3 6.24 5.98 6.4 5.61 5.94 5.57 6.53 100.0 1.41 1.5mg/kg: 1312.88
45 IgG4 2c 1.7e-10 3.6e-11 3.67e-08 8.06 27.7 55.2 >25000 >25000 >25000 5.47 28.6 68.7 2 8 >25000 >25000 1.04e+02 1.56e+02 1.98e+02 30.0 moderate weak moderate weak weak moderate weak 6.37 6.2 6.02 3.82 5.69 4.03 4.29 5.44 100.0 1.85 0.5mg/kg: 372.94|1.5mg/kg: 1152.88
46 IgG1 2.98e-09 3.14e-08 >25000 >25000 >25000 2230.0 3430.0 3800.0 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.14 3.92 3.84 3.72 3.5 3.9 4.85 5.39 6.5 1.23
47 IgG4 2.73e-09 3.18e-09 3.55e-08 4610.0 11000.0 18900.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.54 4.86 3.98 4.25 3.69 3.92 4.85 4.63 24.4 2.53 T588A
48 IgG1 2a 4.28e-10 1.51e-10 1.22e-07 2.19e-08 1150.0 3620.0 13300.0 >25000 >25000 >25000 115.0 696.0 >25000 426 1028 2.82e+03 4.63e+03 6.18e+03 moderate moderate weak weak weak moderate weak 6.22 6.17 5.86 6.22 4.61 4.46 5.02 6.13 100.0 3.14
49 IgG4 2a 3.41e-10 1.36e-10 1.48e-07 1.39e-08 57.4 219.0 506.0 2540.0 3720.0 4100.0 35.7 133.0 259.0 110 256 2.24e+03 9.30e+03 2.14e+04 0.0 moderate moderate moderate weak weak weak weak 6.13 5.75 5.88 3.74 5.57 3.98 4.58 4.61 100.0 2.67 1.5mg/kg: 1233.73
50 IgG1 2a 4.68e-10 1.75e-10 7.87e-08 1.89e-08 869.0 3110.0 6470.0 >25000 >25000 >25000 116.0 398.0 1480.0 70 322 >25000 >25000 4.58e+03 1.11e+04 1.87e+04 strong weak moderate strong weak moderate moderate 6.23 6.19 5.86 6.21 4.63 4.58 5.14 6.12 100.0 1.27 K417E
51 IgG1 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak strong weak moderate strong 4.48 3.87 3.79 3.72 3.46 3.94 4.92 4.72 13.5 0.716
52 IgG1 2a 2.47e-10 1.57e-10 1.71e-09 6.94e-09 221.0 606.0 1080.0 >25000 >25000 >25000 134.0 471.0 739.0 64 187 >25000 >25000 6.07e+02 1.49e+03 2.52e+03 0.0 strong moderate strong strong moderate moderate moderate 6.36 6.29 6.02 6.44 5.65 5.87 5.41 6.56 95.0 1.38 Y489H 1.5mg/kg: 4210.07
53 IgG1 6e-10 2.37e-08 189.0 801.0 1730.0 34.7 185.0 524.0 86.5 559.0 1130.0 95 242 249 800 5.91e+03 9.09e+03 1.17e+04 0.0 moderate weak weak strong weak moderate moderate 5.45 5.44 4.8 4.96 3.5 3.92 4.86 5.19 70.0 1.04 1.5mg/kg: 50.30
54 7a 8.65e-10 2.44e-09 2.44e-07 8.76e-11 1.58e-08 37.0 87.4 139.0 26.4 68.2 111.0 12.9 37.8 64.4 6 22 2 6 2.44e+02 3.44e+02 4.21e+02 weak weak weak moderate weak moderate weak 4.19 3.75 3.86 3.74 3.47 3.9 4.94 4.6 99.5 0.864 S375F|S375F,D1118H
55 IgG1 1.56e-10 5.8e-11 1.15e-07 3.12e-11 1.81e-08 13.1 38.3 70.7 5.98 23.0 48.2 5.47 17.0 30.6 13 27 60 125 2.49e+02 3.85e+02 4.97e+02 0.0 strong moderate moderate strong moderate moderate strong 6.37 6.28 6.01 6.42 5.59 5.74 5.53 6.45 100.0 1.12 1.5mg/kg: 142.39
56 IgG1 1.13e-10 3.82e-11 9.42e-08 1.64e-05 3e-11 1.83e-08 6.36 24.3 51.7 1.52 6.68 16.5 1.74 5.53 10.5 2 7 6 20 1.02e+02 1.77e+02 2.44e+02 0.0 strong weak moderate strong weak moderate moderate 6.33 6.23 5.96 6.34 5.41 5.27 5.34 6.32 100.0 1.86 1.5mg/kg: 50.30
57 1.36e-09 2.28e-09 2.04e-07 1.53e-10 10.2 26.1 45.3 1.06 3.54 7.11 3.08 9.16 17.7 1 5 3 13 5.15e+01 1.21e+02 1.99e+02 92.7 0.66
58 IgG1 7a 2.98e-09 9.59e-10 1.39e-07 5.68e-11 4.6 13.6 24.7 0.805 3.1 6.51 0.45 1.74 3.19 5 16 14 27 8.74e+01 1.11e+02 1.27e+02 strong moderate weak strong weak weak weak 5.29 5.52 3.75 3.65 4.13 4.15 5.41 5.29 100.0 2.12
59 7a 4.76e-10 1.2e-09 2.01e-07 7.63e-11 1.16e-08 3.7 11.8 22.5 1.24 4.07 9.24 2.75 10.4 17.7 1 1 <0.32 4 8.90e+01 1.16e+02 1.35e+02 weak weak weak weak weak moderate weak 3.98 3.75 3.8 3.73 3.46 3.9 4.83 4.7 99.4 0.957 S371F
60 0.45 2 0.37 2 1.34e+01 2.07e+01 2.66e+01 0.486
61 7a 6.2e-10 1.3e-09 1.95e-07 5.25e-11 4.96 15.8 30.8 0.886 4.0 10.2 2.28 8.63 18.5 2 5 <0.32 3 9.05e+01 1.32e+02 1.65e+02 weak moderate weak weak weak moderate weak 4.04 3.78 3.78 3.7 3.46 3.91 4.9 4.86 99.5 0.996 D442A
62 IgG1 7a 2.04e-10 4.77e-11 6.38e-08 1.61e-05 3.55e-11 1.47e-08 8.46 34.5 74.3 4.14 14.1 27.5 7.96 26.0 49.2 4 8 4 15 1.84e+02 3.76e+02 5.71e+02 0.0 moderate strong moderate strong weak moderate moderate 6.32 6.24 5.97 6.36 5.41 5.04 5.32 6.29 100.0 1.32 1.5mg/kg: 50.63
63 7a 4.52e-10 1.07e-09 1.85e-07 6.04e-11 4.26e-09 2.75 10.8 23.4 >25000 >25000 >25000 4.05 11.0 19.1 <0.32 1 <0.32 0.48 1.64e+01 3.65e+01 5.84e+01 weak moderate weak weak weak moderate weak 4.36 3.83 3.78 3.73 3.47 3.93 4.93 4.43 99.8 1.35 Y508H
64 7a 7.08e-10 1.3e-09 1.69e-07 1.34e-10 1.85e-08 11.6 24.6 39.2 25.5 68.3 93.9 2.53 10.3 20.1 3 13 <0.32 4 6.20e+01 8.84e+01 1.09e+02 weak moderate weak weak weak moderate weak 3.94 3.8 3.82 3.73 3.46 3.92 4.86 4.41 96.6 1.16 del374,Y508H|del374,D571G
65 IgG1 7a 1.01e-10 4.01e-11 5.1e-08 2.84e-11 1.92e-08 10.8 29.2 51.1 1.01 5.96 11.1 3.02 10.4 21.1 16 26 18 36 2.50e+02 4.05e+02 5.37e+02 moderate weak moderate strong weak moderate moderate 6.32 6.27 5.97 6.42 5.65 5.77 5.61 6.48 100.0 1.72 K417E
66 5.89e-10 1.14e-09 1.4e-07 1.29e-10 1.88e-08 4.17 11.0 19.5 4.47 15.2 31.9 8.61 26.7 49.6 1 3 <0.32 4 1.12e+02 3.10e+02 5.62e+02 weak weak weak strong weak moderate strong 4.28 4.07 3.88 3.85 3.47 3.9 4.94 4.75 100.0 1.18
67 IgG1 2a 1.39e-09 6.13e-10 2.85e-07 1.81e-10 7.33e-08 17500.0 >25000 >25000 >25000 >25000 >25000 21.7 419.0 1160.0 3404 12080 1.99e+03 3.49e+03 4.85e+03 0.0 strong weak moderate strong weak moderate moderate 6.19 6.13 5.77 6.15 4.77 4.67 5.22 6.22 100.0 1.33 0.5mg/kg: 152.54|1.5mg/kg: 665.62
68 IgG1 2d 4.3e-11 3.61e-11 2.89e-09 2.82e-07 2.05e-09 2.36e-09 9.83 25.8 43.8 >25000 >25000 >25000 10.3 30.1 54.8 1 1 >25000 >25000 5.93e+01 8.74e+01 1.10e+02 None strong strong strong strong moderate moderate strong 6.39 6.33 6.03 6.46 5.73 6.14 5.91 6.59 100.0 1.47 0.5mg/kg: 736.35
69 IgG1 1 1.36e-09 2.2e-10 2.67e-08 7.05e-11 8.92e-10 6840.0 20200.0 >25000 262.0 >25000 >25000 558.0 1730.0 2320.0 482 2470 2.50e+04 2.50e+04 2.50e+04 0.0 strong moderate moderate moderate weak moderate strong 6.32 6.26 5.99 6.41 5.61 5.88 5.28 6.56 74.1 2.52 1.5mg/kg: 501.00
70 RU167-230 D1 Myrio Tx 2.62e-09 3.79e-09 1.3e-07 6.34e-09 606.0 3820.0 9900.0 >25000 >25000 >25000 >25000 >25000 >25000 4929 19977 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak weak weak moderate weak weak weak 4.21 3.9 3.89 3.75 3.48 3.93 5.0 4.72 86.9 1.11
71 RU167-230 D2 Myrio Tx 2.51e-09 1.27e-09 1.29e-07 5.91e-10 876.0 5810.0 18200.0 >25000 >25000 >25000 >25000 >25000 >25000 18221 >25000 >12500 >12500 2.50e+04 2.50e+04 2.50e+04 weak weak moderate moderate weak moderate moderate 4.2 3.87 3.85 5.34 3.47 3.92 5.02 4.72 90.1 1.26
72 RU167-178 D1 Myrio Tx 2.8e-09 3.72e-09 3.14e-08 5.65e-09 137.0 536.0 1110.0 >25000 >25000 >25000 189.0 913.0 2190.0 362 898 >12500 >12500 5.20e+02 1.01e+03 1.48e+03 weak moderate moderate weak weak moderate moderate 4.16 3.81 3.82 3.72 3.48 3.91 4.81 4.43 98.8 0.639
73 RU167-178 D2 Myrio Tx 2a 2.85e-09 4.54e-09 2.49e-08 6.99e-09 302.0 1460.0 3270.0 >25000 >25000 >25000 >25000 >25000 >25000 364 1119 >12500 >12500 3.13e+03 5.68e+03 8.04e+03 weak weak weak weak weak moderate moderate 4.21 4.07 3.87 3.72 3.47 3.95 4.95 4.63 100.0 1.45
74 AB-4001 Generate Biomedicines IgG1 3a 5.52e-10 2.73e-10 3.42e-08 1.44e-10 5.56e-08 78.2 2600.0 9560.0 >25000 >25000 >25000 >25000 >25000 >25000 78 543 44 220 1.55e+03 3.63e+03 5.96e+03 0.0 strong strong moderate weak weak moderate strong 6.22 6.18 5.9 6.27 5.25 4.99 5.28 6.37 96.2 1.7 0.5mg/kg: 511.23|1.5mg/kg: 1286.76
75 AB-4137 Generate Biomedicines IgG1 3a 2.49e-09 1.18e-09 1.27e-07 3.92e-10 8.85e-08 9650.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 379 3034 689 3668 2.50e+04 2.50e+04 2.50e+04 moderate strong moderate weak weak moderate moderate 6.13 6.1 5.8 6.2 5.09 4.88 5.15 6.25 91.3 1.68
76 AB-4138 Generate Biomedicines IgG1 3a 3.62e-09 1.46e-09 1.77e-07 9.63e-10 5.26e-08 17600.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 3548 11060 2214 10897 2.50e+04 2.50e+04 moderate moderate moderate weak weak moderate weak 5.99 6.03 5.71 6.08 4.5 4.42 5.13 6.11 92.6 2.7
77 AB-4163 Generate Biomedicines IgG1 3a 4.34e-09 1.79e-09 3.86e-07 1.07e-09 24600.0 >25000 >25000 >25000 >25000 >25000 833.0 1010.0 1070.0 2.50e+04 2.50e+04 2.50e+04 moderate weak moderate strong weak moderate moderate 5.83 5.82 5.25 5.54 3.5 3.94 4.89 5.53 78.3 1.31
78 Covi9 University of Maryland IgG1 5a 7.18e-10 1.87e-10 3.93e-07 1.35e-10 74.2 224.0 663.0 44.9 164.0 519.0 >25000 >25000 >25000 12 44 10 33 4.61e+01 8.75e+02 4.90e+03 100.0 strong weak moderate strong weak moderate moderate 6.23 6.21 5.91 6.32 5.5 5.57 5.57 6.44 48.7 2.42 del68-69,V70I 0.5mg/kg: 285.14|1.5mg/kg: 1432.71
79 Covi11 University of Maryland IgG1 2a 8.78e-11 6.21e-11 7.45e-10 2.89e-07 3.51e-10 1.01e-08 53.7 140.0 235.0 315.0 >25000 >25000 39.1 80.6 129.0 0.38 3 379 747 2.38e+01 1.76e+02 5.68e+02 10.0 strong strong strong strong moderate moderate moderate 6.36 6.3 6.02 6.43 5.64 5.9 5.43 6.55 99.1 2.93 1.5mg/kg: 8009.08
80 AB-4349 Generate Biomedicines IgG1 3a 2.18e-09 1.21e-09 1.04e-07 5.09e-10 792.0 3340.0 7600.0 371.0 3670.0 >25000 232.0 1270.0 >25000 222 1595 978 3872 3.58e+03 8.52e+03 1.42e+04 0.0 strong moderate moderate strong weak moderate moderate 6.17 6.18 5.88 6.27 5.45 5.36 5.37 6.37 93.7 1.98 1.5mg/kg: 2316.58
81 AB-4350 Generate Biomedicines IgG1 3a 1.47e-09 8.4e-10 9.88e-08 1.52e-10 7.16e-08 824.0 4140.0 9950.0 1390.0 >25000 >25000 227.0 >25000 >25000 100 627 268 736 4.31e+03 1.24e+04 2.30e+04 0.0 strong moderate moderate moderate weak moderate weak 6.19 6.13 5.85 6.24 5.28 5.16 5.26 6.3 86.8 3.09 0.5mg/kg: 397.89|1.5mg/kg: 1106.86
82 AB-3834 Generate Biomedicines IgG1 7b 1.28e-09 1.9e-09 3.61e-08 1.02e-09 >25000 >25000 >25000 >25000 >25000 >25000 1950.0 3020.0 3360.0 20205 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 0.0 strong weak weak weak weak moderate moderate 6.04 6.01 5.61 5.94 4.02 4.12 5.03 5.8 33.1 3.82 1.5mg/kg: 1030.22
83 SEQ-11177 Generate Biomedicines 7a 3.73e-10 2.14e-10 8.94e-08 6.75e-11 4.35e-08 1030.0 3200.0 6030.0 335.0 1140.0 1700.0 380.0 >25000 >25000 99 396 172 503 2.50e+03 2.90e+03 3.16e+03 10.0 strong weak moderate moderate weak moderate moderate 6.3 6.22 5.94 6.28 5.04 5.1 5.29 6.26 98.0 3.84 0.5mg/kg: 1033.55|1.5mg/kg: 9035.08
84 SEQ-11183 Generate Biomedicines 7a 4.33e-10 2.78e-10 9.29e-08 6.99e-11 1.62e-08 1570.0 4380.0 7700.0 374.0 1440.0 2000.0 569.0 2190.0 5470.0 49 175 225 573 1.27e+03 2.07e+03 2.75e+03 0.0 strong weak moderate weak weak moderate moderate 6.31 6.23 5.95 6.32 5.04 5.12 5.31 6.31 96.2 1.36 E654A|R408G 1.5mg/kg: 9120.49
85 AB-4147 Generate Biomedicines IgG1 3a 2.59e-09 8.04e-10 1.51e-07 2.71e-10 1.25e-07 >25000 >25000 >25000 >25000 >25000 >25000 284 786 429 1762 9.62e+03 3.59e+04 7.77e+04 strong moderate moderate weak weak moderate moderate 6.07 6.09 5.73 6.12 4.79 4.63 5.28 6.06 93.2 3.81
86 AB-4153 Generate Biomedicines IgG1 2.16e-09 4.41e-10 1.03e-07 3.15e-10 1.03e-07 6150.0 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 691 4356 1.68e+04 4.58e+04 8.24e+04 moderate moderate moderate weak weak moderate moderate 6.21 6.18 5.92 6.3 5.38 5.42 5.32 6.39 96.8 2.05
87 IgG4 >25000 >25000 >25000 >25000 >25000 >25000 >25000 >25000 2.50e+04 2.50e+04 2.50e+04 weak moderate weak weak weak moderate weak 4.0 3.79 3.62 3.71 3.46 3.9 4.91 4.65 8.2 1.22
88 IgG1
89 MDR504 Tulane IgG1 1 1.22e-09 5.64e-10 6.73e-08 1.49e-10 2.81e-09 536.0 2130.0 4470.0 412.0 1450.0 2380.0 82.5 406.0 >25000 417 1117 4.46e+03 2.17e+04 5.46e+04 0.0 weak moderate weak weak weak moderate moderate 6.07 6.24 5.73 5.62 5.42 3.93 4.13 5.21 60.9 1.44 1.5mg/kg: 114.40
90 414-1 Active Motif IgG1 2c 2.93e-10 1.27e-10 1.1e-07 1.86e-09 380.0 1190.0 2110.0 1040.0 1520.0 1670.0 >25000 >25000 >25000 218 1357 1.89e+03 4.31e+03 6.98e+03 moderate weak moderate strong weak moderate moderate 6.33 6.26 5.97 6.38 5.53 5.74 5.59 6.49 100.0 1.57
91 414-2 Active Motif IgG1 4c 2.43e-10 5.69e-10 4.69e-09 4.46e-06 6.46e-10 3.48e-09 327.0 1660.0 4940.0 814.0 1220.0 1350.0 >25000 >25000 >25000 66 680 4846 10146 2.50e+04 2.50e+04 2.50e+04 None strong weak strong strong moderate moderate moderate 6.26 6.23 5.91 6.34 5.48 5.57 5.53 6.39 21.7 3.92 0.5mg/kg: 1375.38
92 553-63 Active Motif IgG1 2c 1.04e-09 5.73e-10 1.96e-07 208.0 521.0 918.0 >25000 >25000 >25000 >25000 >25000 >25000 144 368 5.92e+02 1.03e+03 1.43e+03 strong moderate moderate moderate weak moderate moderate 6.12 6.08 5.8 6.18 3.8 5.13 5.23 6.17 91.2 1.49
93 eACE2-Ig.v4 Scripps FL IgG2 1 1.02e-10 2.7e-11 4.31e-10 6.52e-07 2.02e-11 69.3 225.0 407.0 26.9 89.8 199.0 26.2 70.1 138.0 >25000 >25000 7.05e+01 9.92e+01 1.21e+02 0.0 moderate weak strong strong weak moderate moderate 6.37 6.32 5.99 3.8 5.77 4.36 4.73 4.56 95.4 1.43 R685S 0.5mg/kg: 66.10|1.5mg/kg: 295.85
94 TB202-3 Twist Bioscience IgG1 4a 1.04e-10 1.1e-10 5.62e-09 4.35e-11 2.77e-11 35.2 96.8 167.0 16.2 42.7 73.1 >25000 >25000 >25000 4 8 2 6 8.87e+01 1.38e+02 1.79e+02 90.0 moderate moderate weak weak weak weak weak 6.18 6.19 5.84 6.08 4.29 4.6 5.42 6.02 98.0 1.64 0.5mg/kg: 2121.07|1.5mg/kg: 7219.93
95 TB202-63 Twist Bioscience IgG1 4a 8.41e-11 4.88e-11 2.75e-08 2.51e-10 3.28e-10 21.2 63.8 122.0 >25000 >25000 >25000 24.2 6.69 3.65 0.34 1 798 14 1.24e+02 3.45e+02 6.26e+02 None strong moderate weak weak weak moderate moderate 6.18 6.12 5.69 6.07 4.3 4.49 5.02 6.15 98.8 1.93 0.5mg/kg: 2508.19
96 Covi17 University of Maryland IgG1 5a 7.65e-11 5.66e-11 9.22e-08 4.7e-11 21.3 59.4 112.0 15.5 78.9 191.0 27.7 114.0 267.0 <0.32 6 0.51 11 5.77e+01 1.76e+02 3.38e+02 None moderate weak weak moderate weak moderate strong 6.02 6.18 5.41 6.01 4.99 4.16 5.09 6.24 44.8 1.26 G339C 0.5mg/kg: 1912.34
97 CV3-1 Fred Hutchinson Cancer Research Center IgG1 1 1.31e-11 6.31e-12 4.96e-09 3.41e-06 1.31e-11 6.2e-09 6.35 19.1 33.5 6.8 32.1 75.1 3.02 9.83 17.7 <0.32 1 <0.32 6 8.25e+01 1.41e+02 1.93e+02 30.0 100.0 1.4 0.5mg/kg: 5702.68
98 IgG1 1 7.35e-11 6.51e-11 3.82e-09 4.23e-11 2.66e-09 130.0 416.0 764.0 26.9 131.0 378.0 50.1 169.0 330.0 18 66 2 14 2.89e+02 4.28e+02 5.38e+02 10.0 strong moderate weak strong weak strong moderate 6.07 6.06 5.37 6.06 4.32 4.17 5.07 6.11 98.5 1.67 0.5mg/kg: 1495.80|1.5mg/kg: 4438.01
99 CC6.35 IAVI IgG1 2c 4.03e-11 2.13e-11 2.47e-09 1.42e-06 1.37e-08 13.8 35.8 60.1 >25000 >25000 >25000 >25000 >25000 >25000 <0.32 <0.32 1605 3436 8.36e+01 1.51e+02 2.14e+02 10.0 strong moderate moderate moderate weak moderate moderate 6.28 6.16 5.95 6.13 4.96 5.37 5.33 6.22 100.0 1.55 0.5mg/kg: 2091.21|1.5mg/kg: 7010.57
100 IgG1 2b 1.45e-11 8.37e-12 3.3e-09 1.61e-06 1.44e-11 3.66e-09 7.45 18.1 29.7 14.0 65.6 165.0 2.87 10.4 21.8 1 3 9 29 1.82e+01 2.93e+01 3.87e+01 80.0 strong strong moderate moderate weak moderate strong 6.28 6.13 6.05 6.19 5.07 5.56 5.21 6.27 100.0 2.19 0.5mg/kg: 3457.40|1.5mg/kg: 12740.40
101 IgG1 4b 2.99e-11 2.26e-11 3.94e-09 2.7e-11 6.43e-11 11.3 27.7 45.2 6.3 20.1 36.8 8.52 45.0 96.2 6 21 9 22 9.78e+01 2.27e+02 3.72e+02 90.0 strong moderate weak moderate weak strong strong 6.26 6.19 6.02 6.11 5.09 5.68 5.58 6.27 100.0 2.7 S494L 0.5mg/kg: 2611.60|1.5mg/kg: 10051.28
102 2b 1.43e-10 6.77e-11 1.45e-09 4.98e-07 3.59e-11 5.78 15.8 27.0 4.47 10.6 17.1 2.81 7.3 10.2 <0.32 <0.32 <0.32 <0.32 2.16e+00 1.06e+01 2.67e+01 0.0 weak weak weak weak weak weak weak 3.84 3.91 3.64 3.33 4.22 3.8 4.63 4.25 84.3 1.3 0.5mg/kg: 50.30|1.5mg/kg: 50.30
103 2b 8.34e-11 1.22e-10 1.62e-09 4.77e-07 5.37e-11 8.82 24.4 42.6 >25000 >25000 20.0 >25000 13.6 26.1 <0.32 <0.32 <0.32 <0.32 2.17e+01 4.28e+01 6.38e+01 weak weak weak weak weak weak weak 3.83 3.71 3.62 3.36 4.17 3.76 4.69 4.27 84.9 1.21
104 2b 9.36e-11 8.39e-11 1.37e-09 6.74e-11 5.15e-10 16.8 26.2 33.8 60.2 204.0 444.0 264.0 631.0 1060.0 <0.32 <0.32 3 7 4.42e+00 6.57e+00 8.28e+00 weak weak weak weak moderate weak weak 3.8 3.74 3.63 3.33 4.22 3.78 4.78 4.24 86.1 1.22
105 62 (AvGn-B) AvantGen IgG1 2d 2.15e-11 1.26e-11 1.62e-08 5.44e-10 335.0 876.0 1520.0 >25000 >25000 >25000 >25000 >25000 >25000 23 68 >25000 >25000 1.86e+02 1.95e+02 2.00e+02 moderate moderate moderate moderate weak moderate weak 6.27 6.19 6.01 6.14 4.36 5.63 5.38 6.25 100.0 1.45 Q493H,R685S
106 G2 AvantGen IgG1 2d 1.3e-11 6.62e-12 9.24e-10 2.79e-07 3.66e-10 6.85 18.4 31.3 >25000 >25000 >25000 >25000 >25000 >25000 <0.32 2 864 2686 1.34e+00 2.12e+00 2.78e+00 None moderate strong moderate weak weak weak weak 6.3 6.14 5.99 6.19 4.82 5.55 5.42 6.25 100.0 1.66 S494L 0.5mg/kg: 4633.30
107 G4 AvantGen IgG1 2d 2.23e-11 1e-11 9.39e-10 2.26e-07 3.61e-10 1.56e-07 8.2 28.9 54.0 >25000 >25000 >25000 >25000 >25000 >25000 <0.32 1 302 889 2.02e+01 2.78e+01 3.36e+01 None strong strong moderate moderate weak moderate moderate 6.31 6.22 6.07 6.18 5.19 5.62 5.41 6.27 100.0 2.09 E406D,S494P 0.5mg/kg: 3584.13
108 H1 AvantGen IgG1 2d 2.28e-11 1.09e-11 1.04e-09 3.6e-07 4.66e-10 1.15e-07 12.3 35.1 62.6 >25000 >25000 >25000 >25000 >25000 >25000 2 5 4915 25000 2.55e+01 4.70e+01 6.73e+01 None strong strong moderate strong weak moderate moderate 6.3 6.18 6.02 6.22 5.08 5.66 5.28 6.26 100.0 1.61 R685S 0.5mg/kg: 3066.01
109 H2 AvantGen IgG1 2d 1.63e-11 1.06e-11 5.8e-10 1.96e-07 3.86e-10 3.59e-08 14.5 32.5 51.4 >25000 >25000 >25000 >25000 >25000 >25000 1 1 5666 18558 1.88e+01 2.58e+01 3.10e+01 strong strong moderate strong weak moderate strong 6.27 6.16 5.99 6.1 4.65 5.41 5.22 6.25 100.0 1.65
110 A1 AvantGen IgG1 2d 2.26e-11 7.08e-12 1.53e-09 7.53e-07 6.18e-10 1.4e-07 18.0 49.5 88.6 >25000 >25000 >25000 2000.0 2040.0 2050.0 2 6 19149 >25000 1.91e+01 3.97e+01 6.10e+01 strong moderate moderate strong weak strong strong 6.3 6.23 6.09 6.18 5.06 5.58 5.3 6.28 100.0 1.9
111 F1 AvantGen IgG1 2d 2.02e-11 1.01e-11 1.39e-09 3.84e-07 3.94e-10 5.42e-08 17.3 44.0 74.2 >25000 >25000 >25000 >25000 >25000 >25000 15 31 16200 >25000 6.71e+01 8.75e+01 1.02e+02 None strong moderate moderate strong weak strong strong 6.29 6.2 6.07 6.19 5.01 5.6 5.5 6.29 100.0 1.77 0.5mg/kg: 3120.30
112 F11 AvantGen IgG1 2d 1.78e-11 9.16e-12 3.46e-10 1.23e-07 3.09e-10 4.14e-08 10.1 26.4 44.2 >25000 >25000 >25000 0.976 >25000 >25000 3 14 8465 23584 2.53e+01 3.77e+01 4.76e+01 None moderate strong moderate strong weak strong strong 6.25 6.18 6.01 6.12 4.88 5.5 5.38 6.27 100.0 1.85 S494P|S494L 0.5mg/kg: 1062.27
113 270 (AvGn-N) AvantGen IgG1 7c 3.71e-10 2.5e-10 1.37e-09 1.48e-10 2.79e-09 9750.0 >25000 >25000 2140.0 5390.0 8490.0 3580.0 9210.0 11700.0 1846 6065 2.50e+04 2.50e+04 2.50e+04 moderate moderate weak strong weak moderate moderate 6.06 6.11 5.48 6.03 4.35 4.54 4.12 6.09 27.2 1.41
114 44 AvantGen IgG1 7c 3.53e-10 2.21e-10 6.2e-10 7.49e-08 1.25e-10 2.08e-09 2660.0 8580.0 15700.0 1290.0 5380.0 7560.0 >25000 >25000 >25000 120 1435 2.50e+04 2.50e+04 2.50e+04 moderate moderate moderate moderate weak moderate moderate 6.0 6.01 5.28 5.98 4.26 4.28 4.85 6.05 31.1 1.96
115 47 AvantGen IgG1 7c 3.79e-10 2.43e-10 8.54e-10 3.57e-07 2.19e-10 2.99e-09 3410.0 11600.0 21200.0 >25000 >25000 >25000 >25000 >25000 >25000 965 2939 1.32e+04 2.78e+04 4.30e+04 moderate moderate moderate strong weak moderate moderate 6.05 6.06 5.27 6.0 4.28 4.45 4.83 6.07 34.5 1.54
116 eCC6.33.1 IAVI IgG1 5a 9.11e-11 5.41e-11 1.03e-08 3.47e-11 2.55e-08 9.43 27.0 47.4 8.93 27.9 45.6 8.91 19.9 29.9 2 5 <0.32 <0.32 5.26e+01 7.77e+01 9.76e+01 90.0 moderate moderate strong strong weak weak moderate 6.03 5.87 5.47 5.9 4.25 4.37 4.92 6.03 29.2 2.1 G339V|G339C|G339F 0.5mg/kg: 667.65|1.5mg/kg: 2646.21
117 IgG1 4b 1.29e-11 6.38e-12 9.06e-10 2.88e-07 3.53e-11 1.31e-11 7.32 16.9 27.3 561.0 2520.0 6210.0 7030.0 >25000 >25000 2 7 0.5 16 1.29e+01 1.51e+01 1.66e+01 80.0 moderate weak moderate weak moderate strong moderate 6.35 6.21 6.23 6.14 6.48 6.06 5.66 6.33 64.6 1.58 0.5mg/kg: 4081.89|1.5mg/kg: 9977.60
118 IgG1 173.0 415.0 710.0 >25000 >25000 >25000 102.0 622.0 1190.0 63 173 542 1823 2.24e+02 3.87e+02 5.32e+02 60.0 moderate strong moderate weak weak moderate moderate 6.31 6.12 6.15 6.18 5.28 5.88 5.8 6.32 100.0 2.33 S371F 0.5mg/kg: 1151.12|5mg/kg: 14018.21
119 7a 1.16e-09 4.52e-10 1.79e-07 5.71e-11 2.69 8.7 16.5 0.907 3.5 8.08 2.03 6.23 12.7 <0.32 3 <0.32 4 1.71e+01 2.28e+01 2.70e+01 weak weak weak weak moderate weak weak 3.89 3.69 3.65 3.57 3.82 3.93 5.44 4.39 100.0 1.2
120